Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor

J. D. Rothstein; A. Guidotti; P. Tinuper; P. Cortelli; P. Avoni; G. Plazzi; E. Lugaresi; P. Montagna; P. Schoch

doi:10.1016/0140-6736(92)93011-B

Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor

J. D. Rothstein, A. Guidotti, P. Tinuper, P. Cortelli, P. Avoni, G. Plazzi, E. Lugaresi, P. Montagna, P. Schoch

School of Medicine

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

"Endozepines" are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.

Original language	English (US)
Pages (from-to)	1002-1004
Number of pages	3
Journal	The Lancet
Volume	340
Issue number	8826
DOIs	https://doi.org/10.1016/0140-6736(92)93011-B
State	Published - Oct 24 1992

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Medicine(all)

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title = "Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor",

abstract = "{"}Endozepines{"} are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.",

author = "Rothstein, {J. D.} and A. Guidotti and P. Tinuper and P. Cortelli and P. Avoni and G. Plazzi and E. Lugaresi and P. Montagna and P. Schoch",

note = "Funding Information: C. L. M. was supported by the Division of Research Resources grant MOI RR0041100 and National Institutes of Health Grant DKI3038. C. W. W. was supported by National Heart Lung and Blood Institute grant HL 39185.",

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AU - Rothstein, J. D.

AU - Guidotti, A.

AU - Tinuper, P.

AU - Cortelli, P.

AU - Avoni, P.

AU - Plazzi, G.

AU - Lugaresi, E.

AU - Montagna, P.

AU - Schoch, P.

N1 - Funding Information: C. L. M. was supported by the Division of Research Resources grant MOI RR0041100 and National Institutes of Health Grant DKI3038. C. W. W. was supported by National Heart Lung and Blood Institute grant HL 39185.

PY - 1992/10/24

Y1 - 1992/10/24

N2 - "Endozepines" are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.

AB - "Endozepines" are endogenous ligands for the benzodiazepine recognition sites on gamma-aminobutyric acid A receptors in the nervous system. Idiopathic recurring stupor (IRS) is a syndrome of spontaneous stupor or coma that is not associated with known metabolic, toxic, or structural abnormalities but can be reversed by flumazenil, a pure benzodiazepine antagonist. We measured endozepine-2 and endozepine-4 by high-performance liquid chromatography and radioreceptor assay in serum and cerebrospinal fluid from three patients with IRS. During episodes of stupor there was a large (up to 300-fold compared with control patients) increase of endozepine-4 content in cerebrospinal fluid and serum, but a return to normal concentrations between attacks. Endozepine-4 may contribute to, or be the cause of, IRS. The reasons for abnormal concentrations of endozepine in blood and brain are unknown.

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Endogenous benzodiazepine receptor ligands in idiopathic recurring stupor

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