Endodermal sinus tumor of the ovary: The M. D. Anderson experience

David M. Gershenson, Gerard Del Junco, Jay Herson, Felix N. Rutledge

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112 Scopus citations


Forty-one patients with pure endodermal sinus tumor of the ovary who were treated at the M. D. Anderson Hospital from 1944 to 1981 are retrospectively reviewed. The median age of these patients was 19 years. The most common presenting symptom was abdominal pain, occurring in 33 patients (80%). No bilateral ovarian involvement was noted at initial surgery. With the exception of 1 patient treated by surgery alone, only patients treated with postoperative combination chemotherapy survived. Twenty-one of the 41 patients are alive and well. Sixteen of 22 patients treated with vincristine, actinomycin-D, and cyclophosphamide have survived. The roles of second-look laparotomy and α-fetoprotein monitoring are discussed. Optimal treatment seems to consist of surgery followed by aggressive combination chemotheraphy.

Original languageEnglish (US)
Pages (from-to)194-202
Number of pages9
JournalObstetrics and gynecology
Issue number2
StatePublished - Feb 1983
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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