Endocrine functions of sclerostin

Ryan C. Riddle

Research output: Contribution to journalReview articlepeer-review


Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation. In this review, we discuss emerging data which suggest that sclerostin also acts outside the skeleton to influence metabolism. In humans, serum sclerostin levels are associated with body mass index and indices of metabolic function. Likewise, genetic mouse models of Sost gene deficiency indicate sclerostin influences adipocyte development and insulin signaling. These data raise the possibility that sclerostin neutralization may be effective at treating two epidemic conditions: osteoporosis and obesity.

Original languageEnglish (US)
Article number100433
JournalCurrent Opinion in Endocrine and Metabolic Research
StatePublished - Feb 2023


  • Adipose
  • Glucose metabolism
  • Osteoblast/osteocyte
  • Sclerostin
  • Wnt signaling

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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