TY - JOUR
T1 - Endocrine disorders in men infected with human immunodeficiency virus
AU - Dobs, Adrian S.
AU - Dempsey, Michael A.
AU - Ladenson, Paul W.
AU - Frank Polk, B.
N1 - Funding Information:
From the Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, and the Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland. This study was supported by Grant NolAl32520 from the National Institutes of Health and The Johns Hopkins Hospital Outpatient Clinic Research Center. Portions of this study were presented at the 69th Annual Meeting of the Endocrine Society, Indianapolis, June 1987. Requests for reprints should be addressed to Dr. Adrian S. Dobs, The Johns Hopkins School of Medicine, Traylor Building, Room 721, 720 Rutland Avenue, Baltimore, Maryland 21205. Manuscript submitted October 8, 1987, and accepted in revised form December 28, 1987.
PY - 1988/3
Y1 - 1988/3
N2 - Gonadal, adrenal, and thyroid functions were evaluated in 70 men seropositive for human immunodeficiency virus (HIV) infection, clinically categorized as asymptomatic (n = 19), AIDS-related complex (ARC) (n = 9), or acquired immunodeficiency syndrome (AIDS) (n = 42). Twenty of 40 men (50 percent) with AIDS were hypogonadal. Mean serum testosterone concentrations in both ARC (292 ± 70 ng/dl) and AIDS (401 ± 30 ng/dl) men were significantly less than in asymptomatic (567 ± 49 ng/dl) or normal men (608 ± 121 ng/dl). Of these hypogonadal men, 18 of 24 (75 percent) had hypogonadotropic hypogonadism. Seven of eight hypogonadal men (88 percent) had a normal gonadotropin response to gonadotropin-releasing hormone administration. Hypogonadism correlated with lymphocyte depletion and weight loss. Adrenal cortisol reserve, evaluated by adrenocorticotropin stimulation, was normal in 36 of 39 patients (92 percent) with AIDS. Indices of thyroid function were normal with the exception of one ARC man with a low free thyroxine index. In conclusion, hypogonadism is common in men with HIV infection and may be the first or most sensitive endocrine abnormality.
AB - Gonadal, adrenal, and thyroid functions were evaluated in 70 men seropositive for human immunodeficiency virus (HIV) infection, clinically categorized as asymptomatic (n = 19), AIDS-related complex (ARC) (n = 9), or acquired immunodeficiency syndrome (AIDS) (n = 42). Twenty of 40 men (50 percent) with AIDS were hypogonadal. Mean serum testosterone concentrations in both ARC (292 ± 70 ng/dl) and AIDS (401 ± 30 ng/dl) men were significantly less than in asymptomatic (567 ± 49 ng/dl) or normal men (608 ± 121 ng/dl). Of these hypogonadal men, 18 of 24 (75 percent) had hypogonadotropic hypogonadism. Seven of eight hypogonadal men (88 percent) had a normal gonadotropin response to gonadotropin-releasing hormone administration. Hypogonadism correlated with lymphocyte depletion and weight loss. Adrenal cortisol reserve, evaluated by adrenocorticotropin stimulation, was normal in 36 of 39 patients (92 percent) with AIDS. Indices of thyroid function were normal with the exception of one ARC man with a low free thyroxine index. In conclusion, hypogonadism is common in men with HIV infection and may be the first or most sensitive endocrine abnormality.
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U2 - 10.1016/0002-9343(88)90144-1
DO - 10.1016/0002-9343(88)90144-1
M3 - Article
C2 - 3348269
AN - SCOPUS:0023968719
SN - 0002-9343
VL - 84
SP - 611
EP - 616
JO - The American journal of medicine
JF - The American journal of medicine
IS - 3 PART 2
ER -