Ending preventable maternal and newborn deaths due to infection

Meghana Desale; Jadsada Thinkhamrop; Pisake Lumbiganon; Shamim Qazi; Jean Anderson

doi:10.1016/j.bpobgyn.2016.05.008

Ending preventable maternal and newborn deaths due to infection

Meghana Desale, Jadsada Thinkhamrop, Pisake Lumbiganon, Shamim Qazi, Jean Anderson

School of Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

Original language	English (US)
Pages (from-to)	116-130
Number of pages	15
Journal	Best Practice and Research: Clinical Obstetrics and Gynaecology
Volume	36
DOIs	https://doi.org/10.1016/j.bpobgyn.2016.05.008
State	Published - Oct 1 2016

Keywords

HIV
malaria
maternal sepsis
neonatal sepsis
respiratory syncytial virus
syphilis

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.bpobgyn.2016.05.008

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title = "Ending preventable maternal and newborn deaths due to infection",

abstract = "Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.",

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AU - Desale, Meghana

AU - Thinkhamrop, Jadsada

AU - Lumbiganon, Pisake

AU - Qazi, Shamim

AU - Anderson, Jean

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

AB - Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

KW - HIV

KW - malaria

KW - maternal sepsis

KW - neonatal sepsis

KW - respiratory syncytial virus

KW - syphilis

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Ending preventable maternal and newborn deaths due to infection

Abstract

Keywords

ASJC Scopus subject areas

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