End-to-end modeling for predicting and estimating radiomics: Application to gray level co-occurrence matrices in ct

Grace J. Gang, Radhika Deshpande, J. Webster Stayman

Research output: Chapter in Book/Report/Conference proceedingConference contribution


While radiomics models are finding increased use in computer-aided diagnostics and as imaging biomarkers for inference and discovery, their utility in computed tomography (CT) is limited by variability of the image properties produced by different CT scanners, imaging protocols, patient anatomy, and an increasingly diverse range of reconstruction and post-processing software. While these effects can be mitigated with careful data curation and standardization of protocols, this is impractical for diverse sources of image data. In this work, we propose to generalize traditional end-to-end imaging system models to include radiomics calculation as an explicit stage. Such a model permits both prediction of the undesirable variability of radiomics, but also forms a basis for inverting the process to estimate the true underlying radiomics. This framework has the potential to provide for standardization of radiomics across imaging conditions permitting more widespread application of radiomics models; larger, more diverse image databases; and improved diagnoses and inferences based on those standardized metrics. We apply this framework to a large class of popular radiomics based on the Gray Level Co-occurrence matrix under conditions of imaging system that are well describe by traditional linear systems approaches as well as nonlinear systems for which traditional analytic models do not apply.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2021
Subtitle of host publicationPhysics of Medical Imaging
EditorsHilde Bosmans, Wei Zhao, Lifeng Yu
ISBN (Electronic)9781510640191
StatePublished - 2021
EventMedical Imaging 2021: Physics of Medical Imaging - Virtual, Online, United States
Duration: Feb 15 2021Feb 19 2021

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2021: Physics of Medical Imaging
Country/TerritoryUnited States
CityVirtual, Online

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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