End-to-end artificial intelligence platform for the management of large vessel occlusions: A preliminary study

Shujuan Meng, Thi My Linh Tran, Mingzhe Hu, Pan Pan Wang, Thomas Yi, Zhusi Zhong, Luoyun Wang, Braden Vogt, Zhicheng Jiao, Arko Barman, Ugur Cetintemel, Ken Chang, Dat Thanh Nguyen, Ferdinand K. Hui, Ian Pan, Bo Xiao, Li Yang, Hao Zhou, Harrison X. Bai

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: In this study, we developed a deep learning pipeline that detects large vessel occlusion (LVO) and predicts functional outcome based on computed tomography angiography (CTA) images to improve the management of the LVO patients. Methods: A series identifier picked out 8650 LVO-protocoled studies from 2015 to 2019 at Rhode Island Hospital with an identified thin axial series that served as the data pool. Data were annotated into 2 classes: 1021 LVOs and 7629 normal. The Inception-V1 I3D architecture was applied for LVO detection. For outcome prediction, 323 patients undergoing thrombectomy were selected. A 3D convolution neural network (CNN) was used for outcome prediction (30-day mRS) with CTA volumes and embedded pre-treatment variables as inputs. Result: For LVO-detection model, CTAs from 8,650 patients (median age 68 years, interquartile range (IQR): 58-81; 3934 females) were analyzed. The cross-validated AUC for LVO vs. not was 0.74 (95% CI: 0.72-0.75). For the mRS classification model, CTAs from 323 patients (median age 75 years, IQR: 63-84; 164 females) were analyzed. The algorithm achieved a test AUC of 0.82 (95% CI: 0.79-0.84), sensitivity of 89%, and specificity 66%. The two models were then integrated with hospital infrastructure where CTA was collected in real-time and processed by the model. If LVO was detected, interventionists were notified and provided with predicted clinical outcome information. Conclusion: 3D CNNs based on CTA were effective in selecting LVO and predicting LVO mechanical thrombectomy short-term prognosis. End-to-end AI platform allows users to receive immediate prognosis prediction and facilitates clinical workflow.

Original languageEnglish (US)
Article number106753
JournalJournal of Stroke and Cerebrovascular Diseases
Volume31
Issue number11
DOIs
StatePublished - Nov 2022

Keywords

  • Artificial intelligence
  • CTA
  • LVO
  • Mechanical thrombectomy
  • Stroke
  • mRS

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Rehabilitation
  • Surgery

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