End-systolic pressure/volume ratio: A new index of ventricular contractility

Kiichi Sagawa, Hiroyuki Suga, Artin A. Shoukas, Kenneth M. Bakalar

Research output: Contribution to journalArticlepeer-review

425 Scopus citations


A thesis recently developed from a series of experiments on the isolated canine left ventricle is described. It is claimed that the ventricular pressure/volume ratio at end-systole is relatively insensitive to cardiac loading and varies greatly in response to changes in ventricular contractility. The clinical viability of this basic finding rests on the substitution of diameter for volume in this formulation. Diameter can be measured using a noninvasive ultrasonic technique in the clinic. Accordingly, end-systolic pressure/diameter ratio was studied in the isolated preparation and found to be similarly insensitive to loading conditions and sensitive to inotropic interventions. A further analysis of the pressure/diameter ratio in the ventricle of the conscious dog is in progress. In parallel with these studies, use of the pressure/diameter ratio to evaluate contractility in cardiac patients is being tested. The preliminary findings from conscious dogs and clinic patients are briefly discussed.

Original languageEnglish (US)
Pages (from-to)748-753
Number of pages6
JournalThe American journal of cardiology
Issue number5
StatePublished - Nov 1977
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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