En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1

Stefanie C. Altieri, Walid Jalabi, Tianna Zhao, Rita R. Romito-DiGiacomo, Stephen M. Maricich

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Little is known about the genetic pathways and transcription factors that control development and maturation of central auditory neurons. En1, a gene expressed by a subset of developing and mature superior olivary complex (SOC) cells, encodes a homeodomain transcription factor important for neuronal development in the midbrain, cerebellum, hindbrain and spinal cord. Using genetic fate-mapping techniques, we show that all En1-lineal cells in the SOC are neurons and that these neurons are glycinergic, cholinergic and GABAergic in neurotransmitter phenotype. En1 deletion does not interfere with specification or neural fate of these cells, but does cause aberrant positioning and subsequent death of all En1-lineal SOC neurons by early postnatal ages. En1-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1. Our data define important roles for En1 in the development and maturation of a diverse group of brainstem auditory neurons.

Original languageEnglish (US)
Pages (from-to)99-108
Number of pages10
JournalDevelopmental biology
Issue number1
StatePublished - Dec 1 2015
Externally publishedYes


  • Auditory
  • Brainstem
  • Deafness
  • Hearing
  • Nucleogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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