Emerging roles of nitric oxide in neurodegeneration

K. K K Chung, Karen K. David

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Nitric oxide (NO) is a gaseous signaling molecule which has physiological and pathological roles in the cell. Under normal conditions, NO is produced by nitric oxide synthase (NOS) and can induce physiological responses such as vasodilation. However, over-activation of NOS has been linked to a number of human pathological conditions. For instance, most neurodegenerative disorders are marked by the presence of nitrated protein aggregates. How nitrosative stress leads to neurodegeneration is not clear, but various studies suggest that increased nitrosative stress causes protein nitration which then leads to protein aggregation. Protein aggregates are highly toxic to neurons and can promote neurodegeneration. In addition to inducing protein aggregation, recent studies show that nitrosative stress can also compromise a number of neuroprotective pathways by modifying activities of certain proteins through S-nitrosylation. These findings suggest that increased nitrosative stress can contribute to neurodegeneration through multiple pathways.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalNitric Oxide - Biology and Chemistry
Issue number4
StatePublished - May 15 2010


  • Neurodegeneration
  • Nitric oxide
  • Parkinson's disease
  • S-nitrosylation

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Clinical Biochemistry
  • Physiology


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