Embryonic Stem Cells as a Cell Source for Tissue Engineering

Ali Khademhosseini, Jeffrey M. Karp, Sharon Gerecht-Nir, Lino Ferreira, Nasim Annabi, Dario Sirabella, Gordana Vunjak-Novakovic, Robert Langer

Research output: Chapter in Book/Report/Conference proceedingChapter


Tissue engineering could generate off-the-shelf organs for transplantation to treat a variety of debilitating ailments such as diabetes or Parkinson's disease. One of the major barriers to the realization of this enormous potential is the lack of renewable sources of cells for transplantation. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPS cells) have the potential to provide such a source of cells because of their ability to differentiate into all somatic cells and their seemingly unlimited proliferative capability. In this chapter, we address the potential and the challenges associated with the use of ESCs in tissue engineering. In particular, we address methods to proliferate and direct ESC differentiation, to isolate and transplant ESCs and to incorporate them into existing tissue engineering approaches. We also address issues associated with the host's immune rejection, ESC-derived tumor formation and scale-up processes.

Original languageEnglish (US)
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Number of pages30
ISBN (Print)9780123983589
StatePublished - Nov 2013
Externally publishedYes


  • Differentiation
  • Embryonic stem cells
  • Induced pluripotent stem cells
  • Progenitor cells
  • Review
  • Scaffolds
  • Self-renewal
  • Tissue engineering
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)


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