Elevated Serum IL-8 Levels in Ataxia Telangiectasia

Sharon A. McGrath-Morrow; J. Michael Collaco; Thomas O. Crawford; Kathryn A. Carson; Maureen A. Lefton-Greif; Pamela Zeitlin; Howard M. Lederman

doi:10.1016/j.jpeds.2009.12.007

Elevated Serum IL-8 Levels in Ataxia Telangiectasia

Sharon A. McGrath-Morrow
, J. Michael Collaco
, Thomas O. Crawford
, Kathryn A. Carson
, Maureen A. Lefton-Greif
, Pamela Zeitlin
, Howard M. Lederman

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

Original language	English (US)
Pages (from-to)	682-684.e1
Journal	Journal of Pediatrics
Volume	156
Issue number	4
DOIs	https://doi.org/10.1016/j.jpeds.2009.12.007
State	Published - Apr 2010

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/j.jpeds.2009.12.007

Cite this

@article{57504d94d62d4d509cc49969b0c55ea4,

title = "Elevated Serum IL-8 Levels in Ataxia Telangiectasia",

abstract = "Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.",

author = "McGrath-Morrow, \{Sharon A.\} and Collaco, \{J. Michael\} and Crawford, \{Thomas O.\} and Carson, \{Kathryn A.\} and Lefton-Greif, \{Maureen A.\} and Pamela Zeitlin and Lederman, \{Howard M.\}",

note = "Funding Information: Supported by the AT Children's Project , National Center for Research Resources , a component of the National Institutes of Health (NIH); NIH Roadmap for Medical Research Grant UL1RR 025005 (to K.C.); and Johns Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005 (to S.M.-M., T.C., P.Z., and H.L.). The authors declare no conflicts of interest. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2010",

month = apr,

doi = "10.1016/j.jpeds.2009.12.007",

language = "English (US)",

volume = "156",

pages = "682--684.e1",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Elevated Serum IL-8 Levels in Ataxia Telangiectasia

AU - McGrath-Morrow, Sharon A.

AU - Collaco, J. Michael

AU - Crawford, Thomas O.

AU - Carson, Kathryn A.

AU - Lefton-Greif, Maureen A.

AU - Zeitlin, Pamela

AU - Lederman, Howard M.

N1 - Funding Information: Supported by the AT Children's Project , National Center for Research Resources , a component of the National Institutes of Health (NIH); NIH Roadmap for Medical Research Grant UL1RR 025005 (to K.C.); and Johns Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005 (to S.M.-M., T.C., P.Z., and H.L.). The authors declare no conflicts of interest. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2010/4

Y1 - 2010/4

N2 - Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

AB - Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.

UR - https://www.scopus.com/pages/publications/77949492325

UR - https://www.scopus.com/pages/publications/77949492325#tab=citedBy

U2 - 10.1016/j.jpeds.2009.12.007

DO - 10.1016/j.jpeds.2009.12.007

M3 - Article

C2 - 20171651

AN - SCOPUS:77949492325

SN - 0022-3476

VL - 156

SP - 682-684.e1

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 4

ER -

Elevated Serum IL-8 Levels in Ataxia Telangiectasia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this