TY - JOUR
T1 - Elevated IgE from attenuated CARD11 signaling
T2 - lessons from atopic mice and humans
AU - Pomerantz, Joel L.
AU - Milner, Joshua D.
AU - Snow, Andrew L.
N1 - Publisher Copyright:
© 2022
PY - 2022/12
Y1 - 2022/12
N2 - CARD11 encodes a large scaffold protein responsible for integrating antigen-receptor engagement with downstream signaling to NF-kB and other outputs in lymphocytes. Over the past 10 years, several human-inborn errors of immunity have been linked to pathogenic CARD11 mutations. Most recently, severe atopic patients were discovered that carried heterozygous dominant-negative CARD11 mutations. Here, we review the mechanistic connections between attenuated CARD11 signaling, elevated IgE, and atopy, comparing and contrasting key insights from both human patients and murine models. Continued investigation of abnormal CARD11 signaling in both contexts should inform novel therapeutic strategies to combat allergic pathogenesis.
AB - CARD11 encodes a large scaffold protein responsible for integrating antigen-receptor engagement with downstream signaling to NF-kB and other outputs in lymphocytes. Over the past 10 years, several human-inborn errors of immunity have been linked to pathogenic CARD11 mutations. Most recently, severe atopic patients were discovered that carried heterozygous dominant-negative CARD11 mutations. Here, we review the mechanistic connections between attenuated CARD11 signaling, elevated IgE, and atopy, comparing and contrasting key insights from both human patients and murine models. Continued investigation of abnormal CARD11 signaling in both contexts should inform novel therapeutic strategies to combat allergic pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=85140969346&partnerID=8YFLogxK
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U2 - 10.1016/j.coi.2022.102255
DO - 10.1016/j.coi.2022.102255
M3 - Review article
C2 - 36334349
AN - SCOPUS:85140969346
SN - 0952-7915
VL - 79
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
M1 - 102255
ER -