TY - JOUR
T1 - Elevated cytokine levels in children with autism spectrum disorder
AU - Molloy, Cynthia A.
AU - Morrow, Ardythe L.
AU - Meinzen-Derr, Jareen
AU - Schleifer, Kathleen
AU - Dienger, Krista
AU - Manning-Courtney, Patricia
AU - Altaye, Mekibib
AU - Wills-Karp, Marsha
N1 - Funding Information:
We extend our deepest thanks to the children and families who participated in this study. We also thank Betsy List, RN, Rachel Akers, MPH and Jen Andringa for their help in collecting and managing the data. The study was supported by a pilot project grant from the Cure Autism Now Foundation. The General Clinical Research Center was funded by NIH grant MO1 RR 08084.
PY - 2006/3
Y1 - 2006/3
N2 - This study compared production of IL-2, IFN-γ, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-γ/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-γ/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
AB - This study compared production of IL-2, IFN-γ, IL-4, IL-13, IL-5 and IL-10 in peripheral blood mononuclear cells from 20 children with autism spectrum disorder to those from matched controls. Levels of all Th2 cytokines were significantly higher in cases after incubation in media alone, but the IFN-γ/IL-13 ratio was not significantly different between cases and controls. Cases had significantly higher IL-13/IL-10 and IFN-γ/IL-10 than controls. Conclusion: Children with ASD had increased activation of both Th2 and Th1 arms of the adaptive immune response, with a Th2 predominance, and without the compensatory increase in the regulatory cytokine IL-10.
KW - Adaptive immune responses
KW - Autism
KW - Cytokines
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U2 - 10.1016/j.jneuroim.2005.11.007
DO - 10.1016/j.jneuroim.2005.11.007
M3 - Article
C2 - 16360218
AN - SCOPUS:33244493984
SN - 0165-5728
VL - 172
SP - 198
EP - 205
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -