Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease

M. A. Lovell, W. D. Ehmann, M. P. Mattson, W. R. Markesbery

Research output: Contribution to journalArticlepeer-review

346 Scopus citations


4-Hydroxynonenal (4-HNE), an aldehyde by-product of the peroxidation of fatty acids, has been shown to have toxic properties for neurons in culture. In light of increasing evidence that oxidative stress contributes to the neurodegenerative process in Alzheimer's disease (AD) we quantified levels of free and protein-bound 4-HNE in the ventricular fluid from 19 AD subjects and 13 control subjects by high-pressure liquid chromatography and dot-blot immunoassay. Free 4-HNE levels were found to be significantly elevated in the ventricular fluid of AD subjects compared with control subjects (p = 0.0096). These results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalNeurobiology of Aging
Issue number5
StatePublished - Sep 1997
Externally publishedYes


  • 4-Hydroxynonenal
  • Alzheimer's disease
  • Lipid peroxidation
  • Oxidative stress
  • Ventricular fluid

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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