Elevated β-hCG associated with aggressive Osteoblastoma

Carol D Morris, Meera R. Hameed, Narasimhan P. Agaram, Sinchun Hwang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We present a unique case of an aggressive scapular osteoblastoma that produced β-hCG as a paraneoplastic manifestation in a 20-year-old woman. Serum β-hCG was found to be elevated during presurgical workup and consequently delayed surgical resection of the increasingly painful tumor because of suspected pregnancy. The paraneoplastic production of β-hCG was later proven by positive immunohistochemical stain of β-hCG in a curettage specimen and normalization of β-hCG levels after surgical resection of the aggressive osteoblastoma. Production of beta-human chorionic gonadotropin (β-hCG) has been reported in several carcinomas and sarcomas but, to our knowledge, it has not been reported in osteoblastoma in the English-language literature.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalSkeletal Radiology
StateAccepted/In press - Apr 10 2017


  • Beta-human chorionic gonadotropin
  • Osteoblastoma, paraneoplastic
  • β-hCG

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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