TY - JOUR
T1 - Electronic nicotine delivery systems
T2 - Comparative topography assessments
AU - Koszowski, Bartosz
AU - Salazar, Esther
AU - Thanner, Meridith Hill
AU - Pickworth, Wallace B.
AU - Paredes, Antonio
AU - Schroeder, Megan J.
N1 - Funding Information:
Support for this research was provided by a contract awarded to Battelle by the Food and Drug Administration, Center for Tobacco Products (FDA/ CTP). This publication represents the views of the authors and does not represent FDA/CTP position or policy. The authors thank Arielle Pietron and Jasmine Offoha for editorial assistance.
Publisher Copyright:
© 2020, Tobacco Regulatory Science Group. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objectives: Due to rapidly emerging electronic nicotine delivery system (ENDS) technologies, increasing use in the US, and the unclear impact on users’ health, investigating behavior associated with ad libitum ENDS use is an important research topic. ENDS use behavior is typically assessed either by direct observation or through smoking topography recording units; however, systematic comparisons between these methods are lacking. Therefore, we sought to compare 2 common methods to quantify ENDS topography. Methods: Current ENDS users (N = 18) used their own brand ENDS ad libitum in a clinical laboratory. We compared smoking topography-based recording units (desktop Clinical Research Support System; CReSS) and observational video-recordings with frame-by-frame (FxF) analysis methods to quantify ENDS topography. Results: Although CReSS analyses tended to estimate higher puff count and shorter average puff duration than FxF analyses, estimates of total puff duration were not different. Furthermore, both topography analysis methods showed significant associations with estimated nicotine in-take. Conclusions: Neither the CReSS nor the FxF method is suited perfectly for analyzing ENDS topography. However, because FxF analysis is time-consuming and cumbersome, smoking topography-based recording unit methods may offer a more practical approach to measure ENDS topography; however, researchers must consider its limitations.
AB - Objectives: Due to rapidly emerging electronic nicotine delivery system (ENDS) technologies, increasing use in the US, and the unclear impact on users’ health, investigating behavior associated with ad libitum ENDS use is an important research topic. ENDS use behavior is typically assessed either by direct observation or through smoking topography recording units; however, systematic comparisons between these methods are lacking. Therefore, we sought to compare 2 common methods to quantify ENDS topography. Methods: Current ENDS users (N = 18) used their own brand ENDS ad libitum in a clinical laboratory. We compared smoking topography-based recording units (desktop Clinical Research Support System; CReSS) and observational video-recordings with frame-by-frame (FxF) analysis methods to quantify ENDS topography. Results: Although CReSS analyses tended to estimate higher puff count and shorter average puff duration than FxF analyses, estimates of total puff duration were not different. Furthermore, both topography analysis methods showed significant associations with estimated nicotine in-take. Conclusions: Neither the CReSS nor the FxF method is suited perfectly for analyzing ENDS topography. However, because FxF analysis is time-consuming and cumbersome, smoking topography-based recording unit methods may offer a more practical approach to measure ENDS topography; however, researchers must consider its limitations.
KW - CReSS
KW - E-cigarettes
KW - Electronic nicotine delivery systems (ENDS)
KW - Topography
KW - Use behavior
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U2 - 10.18001/TRS.6.1.6
DO - 10.18001/TRS.6.1.6
M3 - Article
AN - SCOPUS:85107698788
SN - 2333-9748
VL - 6
SP - 54
EP - 65
JO - Tobacco Regulatory Science
JF - Tobacco Regulatory Science
IS - 1
ER -