@article{666cd18431a14e12a53253bc6c39bc24,
title = "Electrical brain stimulation in different variants of primary progressive aphasia: A randomized clinical trial",
abstract = "Introduction: Transcranial direct current stimulation (tDCS) has been recently shown to improve language outcomes in primary progressive aphasia (PPA) but most studies are small and the influence of PPA variant is unknown. Methods: Thirty-six patients with PPA participated in a randomized, sham-controlled, double-blind, within-subject crossover design for 15 daily sessions of stimulation coupled with written naming/spelling therapy. Outcome measures were letter accuracy of treated and untreated words immediately after and at 2 weeks and 2 months posttreatment. Results: tDCS treatment was more effective than sham: gains for treated words were maintained 2 months posttreatment; gains from tDCS also generalized to untreated words and were sustained 2 months posttreatment. Different effects were obtained for each PPA variant, with no tDCS advantage for semantic variant PPA. Discussion: The study supports using tDCS as an adjunct to written language interventions in individuals with logopenic or nonfluent/agrammatic PPA seeking compensatory treatments in clinical settings.",
keywords = "Alzheimer's disease, Dementia, Frontotemporal dementia, Language, Naming, Primary progressive aphasia, Spelling, Treatment, lvPPA, nfvPPA, svPPA",
author = "Kyrana Tsapkini and Webster, {Kimberly T.} and Ficek, {Bronte N.} and Desmond, {John E.} and Onyike, {Chiadi U.} and Brenda Rapp and Frangakis, {Constantine E.} and Hillis, {Argye E.}",
note = "Funding Information: Funding: This work was supported by grants from the Science of Learning Institute at Johns Hopkins University and by the National Institutes of Health ( National Institute of Deafness and Communication Disorders ) through award R01 DC014475 to K.T. A.H. was supported by NIH ( NIDCD ) through awards R01 DC05375 , R01 DC011317 , and P50 DC014664 ; B.R. was supported by NIDCD P50 006740 . C.U.O. was supported by the Jane Tanger Black Fund for Young-Onset Dementias and the Nancy H. Hall Fund for Geriatric Psychiatry. Funding Information: Funding: This work was supported by grants from the Science of Learning Institute at Johns Hopkins University and by the National Institutes of Health (National Institute of Deafness and Communication Disorders) through award R01 DC014475 to K.T. A.H. was supported by NIH (NIDCD) through awards R01 DC05375, R01 DC011317, and P50 DC014664; B.R. was supported by NIDCD P50 006740. C.U.O. was supported by the Jane Tanger Black Fund for Young-Onset Dementias and the Nancy H. Hall Fund for Geriatric Psychiatry. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.trci.2018.08.002",
language = "English (US)",
volume = "4",
pages = "461--472",
journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier Inc.",
}