El Tor cholera with severe disease: A new threat to Asia and beyond

A. K. Siddique, G. B. Nair, M. Alam, D. A. Sack, A. Huq, A. Nizam, I. M. Longini, F. Qadri, S. M. Faruque, R. R. Colwell, S. Ahmed, A. Iqbal, N. A. Bhuiyan, R. B. Sack

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


During epidemics of cholera in two rural sites (Bakerganj and Mathbaria), a much higher proportion of patients came for treatment with severe dehydration than was seen in previous years. V. cholerae O1 isolated from these patients was found to be El Tor in its phenotype, but its cholera toxin (CT) was determined to be that of classical biotype. Whether the observed higher proportion of severe dehydration produced by the El Tor biotype was due to a shift from El Tor to classical CT or due to other factors is not clear. However, if cholera due to strains with increased severity spread to other areas where treatment facilities are limited, there are likely to be many more cholera deaths.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalEpidemiology and infection
Issue number3
StatePublished - Mar 2010


  • Cholera
  • El Tor toxin
  • Epidemic
  • Severe dehydration
  • Vibrio cholerae

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases


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