An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.
|Original language||English (US)|
|Number of pages||2|
|State||Published - May 13 2004|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry