Efficient induction of protective anti-malaria immunity by recombinant adenovirus

Elaine G. Rodrigues; Fidel Zavala; Ruth S. Nussenzweig; James M. Wilson; Moriya Tsuji

doi:10.1016/S0264-410X(98)00181-9

Efficient induction of protective anti-malaria immunity by recombinant adenovirus

Elaine G. Rodrigues, Fidel Zavala, Ruth S. Nussenzweig, James M. Wilson, Moriya Tsuji

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.

Original language	English (US)
Pages (from-to)	1812-1817
Number of pages	6
Journal	Vaccine
Volume	16
Issue number	19
DOIs	https://doi.org/10.1016/S0264-410X(98)00181-9
State	Published - Nov 1998
Externally published	Yes

Keywords

Adenovirus
Malaria
Protection

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/S0264-410X(98)00181-9

Cite this

@article{f417d9a4333f469b8665fdd4f40fe163,

title = "Efficient induction of protective anti-malaria immunity by recombinant adenovirus",

abstract = "The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.",

keywords = "Adenovirus, Malaria, Protection",

author = "Rodrigues, {Elaine G.} and Fidel Zavala and Nussenzweig, {Ruth S.} and Wilson, {James M.} and Moriya Tsuji",

note = "Funding Information: We thank Mr Jeremy Claassen for critically reviewingt he manuscripta nd MS Donna Sosnoskia nd Mr Chui Ng for their technical assistanceT. his work was supportedb y Grants AI-27458 and AI-40656 from the National Institute of Health. E.G.R. is supported by a fellowship from the Brazilian National Research Council.",

year = "1998",

month = nov,

doi = "10.1016/S0264-410X(98)00181-9",

language = "English (US)",

volume = "16",

pages = "1812--1817",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier Ltd",

number = "19",

}

TY - JOUR

T1 - Efficient induction of protective anti-malaria immunity by recombinant adenovirus

AU - Rodrigues, Elaine G.

AU - Zavala, Fidel

AU - Nussenzweig, Ruth S.

AU - Wilson, James M.

AU - Tsuji, Moriya

N1 - Funding Information: We thank Mr Jeremy Claassen for critically reviewingt he manuscripta nd MS Donna Sosnoskia nd Mr Chui Ng for their technical assistanceT. his work was supportedb y Grants AI-27458 and AI-40656 from the National Institute of Health. E.G.R. is supported by a fellowship from the Brazilian National Research Council.

PY - 1998/11

Y1 - 1998/11

N2 - The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.

AB - The immunogenicity of a previously constructed replication-defective recombinant adenovirus expressing the CS protein of Plasmodium yoelii was compared with that of irradiated sporozoites. We found that immunization of BALB/c mice with a single dose of this recombinant adenovirus induced a much greater CS-specific T-cell response compared with immunization with irradiated sporozoites. More importantly, we found that this recombinant adenovirus induces similar or higher levels of protective immunity than those induced by irradiated sporozoites, eliciting an appreciable resistance to malaria infection.

KW - Adenovirus

KW - Malaria

KW - Protection

UR - http://www.scopus.com/inward/record.url?scp=0032210888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032210888&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(98)00181-9

DO - 10.1016/S0264-410X(98)00181-9

M3 - Article

C2 - 9795385

AN - SCOPUS:0032210888

SN - 0264-410X

VL - 16

SP - 1812

EP - 1817

JO - Vaccine

JF - Vaccine

IS - 19

ER -

Efficient induction of protective anti-malaria immunity by recombinant adenovirus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this