Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis

Sassan Noazin; Ali Khamesipour; Lawrence H. Moulton; Marcel Tanner; Kiumarss Nasseri; Farrokh Modabber; Iraj Sharifi; E. A.G. Khalil; Ivan Dario Velez Bernal; Carlos M.F. Antunes; Peter G. Smith

doi:10.1016/j.vaccine.2009.05.084

Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis

Sassan Noazin, Ali Khamesipour, Lawrence H. Moulton, Marcel Tanner, Kiumarss Nasseri, Farrokh Modabber, Iraj Sharifi, E. A.G. Khalil, Ivan Dario Velez Bernal, Carlos M.F. Antunes, Peter G. Smith

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with "first-generation" whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.

Original language	English (US)
Pages (from-to)	4747-4753
Number of pages	7
Journal	Vaccine
Volume	27
Issue number	35
DOIs	https://doi.org/10.1016/j.vaccine.2009.05.084
State	Published - Jul 30 2009
Externally published	Yes

Keywords

Clinical trial
Leishmaniasis vaccine
Meta-analysis

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2009.05.084

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title = "Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis",

abstract = "Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with {"}first-generation{"} whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.",

keywords = "Clinical trial, Leishmaniasis vaccine, Meta-analysis",

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doi = "10.1016/j.vaccine.2009.05.084",

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AU - Noazin, Sassan

AU - Khamesipour, Ali

AU - Moulton, Lawrence H.

AU - Tanner, Marcel

AU - Nasseri, Kiumarss

AU - Modabber, Farrokh

AU - Sharifi, Iraj

AU - Khalil, E. A.G.

AU - Bernal, Ivan Dario Velez

AU - Antunes, Carlos M.F.

AU - Smith, Peter G.

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with "first-generation" whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.

AB - Despite decades of investigation in countries on three continents, an efficacious vaccine against Leishmania infections has not been developed. Although some indication of protection was observed in some of the controlled trials conducted with "first-generation" whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published or unpublished randomized, controlled field efficacy clinical trials of prophylactic candidate vaccines, a meta-analysis of qualified trials was conducted to evaluate whether there was some evidence of protection revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis.

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Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis-A meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

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