Efficacy of an accelerated hepatitis b vaccination program during pregnancy

Jeanne S. Sheffield, Ashley Hickman, Jennifer Tang, Kristie Moss, Atoosa KouroS.H., Natalie M. Crawford, George D. Wendel

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective: To estimate the feasibility and immunogenicity of an accelerated hepatitis B vaccination schedule of 0, 1, and 4 months in high-risk pregnant women. Methods:We conducted a prospective clinical trial of high-risk pregnant women who were hepatitis B surface antigen-negative at presentation for prenatal care. A detailed questionnaire was administered and eligible women received a hepatitis B vaccine intramuscularly on a 0-, 1-, and 4-month schedule. Adverse reactions and hepatitis B surface antigen seroconversion rates were documented. Factors influencing seroconversion were determined. Rssults: Two hundred high-risk pregnant women were enrolled; 84% completed the three-dose vaccine series. Seroconversion (hepatitis B surface antigen 10 milli-international units/mL or greater) after one dose was 56% (95% confidence interval [CI], 49-63%), 77% (95% CI, 71-83%) after two doses, and 90% (95% CI, 85-94%) after completing three doses. Body mass index was inversely associated with seroconversion rates (P<.001). There was no single body mass index above which seroconversion did not occur. There were no serious adverse events; injection site discomfort was the most prevalent complaint (10.5%). CONCLUSION:: An accelerated hepatitis B vaccination schedule at 0, 1, and 4 months in high-risk pregnant women is effective, practical, and well tolerated. This accelerated vaccine strategy can be completed during the course of pregnancy and provides another means of decreasing hepatitis B virus disease and transmission.

Original languageEnglish (US)
Pages (from-to)1130-1135
Number of pages6
JournalObstetrics and gynecology
Issue number5
StatePublished - May 2011
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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