Efficacy of a live oral cholera vaccine in human volunteers.

W. E. Woodward; R. H. Gilman; R. B. Hornick; J. P. Libonati; R. A. Cash

Efficacy of a live oral cholera vaccine in human volunteers.

W. E. Woodward, R. H. Gilman, R. B. Hornick, J. P. Libonati, R. A. Cash

Research output: Contribution to journal › Article › peer-review

Abstract

A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.

Original language	English (US)
Pages (from-to)	108-112
Number of pages	5
Journal	Developments in biological standardization
Volume	33
State	Published - Jan 1 1976
Externally published	Yes

ASJC Scopus subject areas

General Immunology and Microbiology
Drug Discovery
Public Health, Environmental and Occupational Health

Cite this

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title = "Efficacy of a live oral cholera vaccine in human volunteers.",

abstract = "A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.",

author = "Woodward, {W. E.} and Gilman, {R. H.} and Hornick, {R. B.} and Libonati, {J. P.} and Cash, {R. A.}",

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AU - Gilman, R. H.

AU - Hornick, R. B.

AU - Libonati, J. P.

AU - Cash, R. A.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.

AB - A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.

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AN - SCOPUS:0016908378

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ER -

Efficacy of a live oral cholera vaccine in human volunteers.

Abstract

ASJC Scopus subject areas

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