Efficacy and safety of routine blood pressure lowering in older patients with diabetes: Results from the advance trial

Toshiharu Ninomiya, Sophia Zoungas, Bruce Neal, Mark Woodward, Anushka Patel, Vlado Perkovic, Alan Cass, Mark Cooper, Diederick Grobbee, Pavel Hamet, Stephen Harrap, Lisheng Liu, Giuseppe Mancia, Carl Erik Mogensen, Neil Poulter, Anthony Rodgers, Bryan Williams, Stephen MacMahon, John Chalmers

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Objective: The efficacy and safety of blood pressure lowering in elderly patients have not been sufficiently investigated in patients with diabetes. Using data from the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation study, we assessed the efficacy and safety of routine blood pressure lowering to prevent major clinical outcomes in elderly patients with type 2 diabetes. Methods: Eleven thousand one hundred and forty patients aged at least 55 years with type 2 diabetes (mean 66 ± 6 years) were randomly assigned to perindopril-indapamide or placebo. The primary endpoint was a composite of major macrovascular and microvascular disease. The effects of active treatment on outcomes were estimated in subgroups according to age: below 65, 65-74 and at least 75 years. Results: During a mean 4.3-year follow-up, 1799 (16.1%) patients experienced a major event. Active treatment produced similar relative risk reductions for the primary outcome, major macrovascular disease, death and renal events across age groups (all P heterogeneity >0.3). Over 5 years, active treatment was estimated to prevent one primary outcome in every 21, 71 and 118 patients of at least75, 65-74 and below 65 years, respectively. Similar patterns of benefits were observed for secondary outcomes. There were no differences in the tolerability between randomized allocations across age groups (all P heterogeneity >0.6) Conclusion: Routine administration of perindopril-indapamide lowers blood pressure safely and reduces the risk of major clinical outcomes in patients of at least 75 years with type 2 diabetes. The greater absolute benefits in older patients in this age group were not offset by an increased risk of side effects.

Original languageEnglish (US)
Pages (from-to)1141-1149
Number of pages9
JournalJournal of hypertension
Issue number6
StatePublished - Jun 2010


  • Age
  • Blood pressure
  • Blood pressure lowering
  • Cardiovascular disease
  • Elderly
  • Perindopril-indapamide

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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