Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

C. N. Ghent; J. R. Bloomer; Y. E. Hsia; Paul S. Lietman

doi:10.1016/S0022-3476(78)80625-8

Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

C. N. Ghent
, J. R. Bloomer
, Y. E. Hsia
, Paul S. Lietman

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of ¹³¹I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

Original language	English (US)
Pages (from-to)	127-132
Number of pages	6
Journal	The Journal of pediatrics
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(78)80625-8
State	Published - Jul 1978

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(78)80625-8

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@article{4dc2a23b9f8340ab8f4410d8e51f2ff2,

title = "Efficacy and safety of long-term phenobarbital therapy of familial cholestasis",

abstract = "Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.",

author = "Ghent, \{C. N.\} and Bloomer, \{J. R.\} and Hsia, \{Y. E.\} and Lietman, \{Paul S.\}",

note = "Funding Information: From the Departments of Medicbw and Hmnan Genetics, \}'ale Universit){"} School of Medicine. Supported in part b)': Childrens Clinical Research Grant RR 125, Public Health Service Center Grant GN 20124, Training Grant 1LD. 00198, National Foundation-March of Dhnes MedJ'cal Service Grant C-143, attd United States Public Health Service Trahting Grant AM 5180-15. Dr. Ghent was supported b){"} the R. Samuel McLaughlin Foundation and the Canadian Hepatic \textasciitilde{}btmdation. Dr. Bloomer is an Investigator. Howard Hughes Medical hlstitute. {"}Reprint address: Department of Medicine, Universitr llospital. London, Ontario. Canada. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1978",

month = jul,

doi = "10.1016/S0022-3476(78)80625-8",

language = "English (US)",

volume = "93",

pages = "127--132",

journal = "The Journal of pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

AU - Ghent, C. N.

AU - Bloomer, J. R.

AU - Hsia, Y. E.

AU - Lietman, Paul S.

N1 - Funding Information: From the Departments of Medicbw and Hmnan Genetics, }'ale Universit)" School of Medicine. Supported in part b)': Childrens Clinical Research Grant RR 125, Public Health Service Center Grant GN 20124, Training Grant 1LD. 00198, National Foundation-March of Dhnes MedJ'cal Service Grant C-143, attd United States Public Health Service Trahting Grant AM 5180-15. Dr. Ghent was supported b)" the R. Samuel McLaughlin Foundation and the Canadian Hepatic ~btmdation. Dr. Bloomer is an Investigator. Howard Hughes Medical hlstitute. "Reprint address: Department of Medicine, Universitr llospital. London, Ontario. Canada. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/7

Y1 - 1978/7

N2 - Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

AB - Two brothers with progressive familial intraheptic cholestasis were followed during four years of phenobarbital therapy to assess its long-term safety and efficacy. Effects attributable to phenobarbital included sustained relief of pruritus, lowering of serum bilirubin levels, and enhanced hepatic excretion of 131I-rose bengal; serum bile acid levels were only transiently decreased. Two brief interruptions in therapy resulted in symptomatic deterioration. Phenobarbital did not retard growth nor impede the response to vitamin D therapy of concomitant rickets.

UR - https://www.scopus.com/pages/publications/0017810790

UR - https://www.scopus.com/pages/publications/0017810790#tab=citedBy

U2 - 10.1016/S0022-3476(78)80625-8

DO - 10.1016/S0022-3476(78)80625-8

M3 - Article

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AN - SCOPUS:0017810790

SN - 0022-3476

VL - 93

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EP - 132

JO - The Journal of pediatrics

JF - The Journal of pediatrics

IS - 1

ER -

Efficacy and safety of long-term phenobarbital therapy of familial cholestasis

Abstract

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