TY - JOUR
T1 - Effects of Vitamin D on Physical Function
T2 - Results From the STURDY Trial
AU - STURDY Collaborative Research Group
AU - Guralnik, Jack M.
AU - Sternberg, Alice L.
AU - Mitchell, Christine M.
AU - Blackford, Amanda L.
AU - Schrack, Jennifer
AU - Wanigatunga, Amal A.
AU - Michos, Erin
AU - Juraschek, Stephen P.
AU - Szanton, Sarah
AU - Kalyani, Rita
AU - Cai, Yurun
AU - Appel, Lawrence J.
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Background: Studies of the relationship between vitamin D and physical functioning have had inconsistent results. Methods: Physical functioning measures were collected for up to 2 years during a 2-stage, Bayesian, response-adaptive, randomized trial of 4 doses of vitamin D3 supplementation (200 [control], 1 000, 2 000, and 4 000 IU/day) to prevent falls. Two community-based research units enrolled adults aged ≥70 years, with elevated fall risk and serum 25-hydroxyvitamin D level of 10-29 ng/mL. The Pooled Higher Doses (PHD) group (≥1 000 IU/day, n = 349) was compared to the control group (n = 339) on changes in Short Physical Performance Battery (SPPB) score and its component tests, Timed Up-and-Go (TUG) test, 6-minute walk distance, and grip strength. Results: The trial enrolled 688 participants. Mean age was 77.2 years, 56.4% were male, 79.7% White, and 18.2% Black. While the PHD and control groups both lost function over time on most outcomes, the 2 groups did not show differential change overall on any outcome. Incidence of transitioning to poor functioning on gait speed, SPPB score, or TUG test did not differ by dose group. Conclusion: In older persons with low serum 25-hydroxyvitamin D level and elevated fall risk, high-dose vitamin D supplementation, ≥1 000 IU/day, did not improve measures of physical function compared to 200 IU/day.
AB - Background: Studies of the relationship between vitamin D and physical functioning have had inconsistent results. Methods: Physical functioning measures were collected for up to 2 years during a 2-stage, Bayesian, response-adaptive, randomized trial of 4 doses of vitamin D3 supplementation (200 [control], 1 000, 2 000, and 4 000 IU/day) to prevent falls. Two community-based research units enrolled adults aged ≥70 years, with elevated fall risk and serum 25-hydroxyvitamin D level of 10-29 ng/mL. The Pooled Higher Doses (PHD) group (≥1 000 IU/day, n = 349) was compared to the control group (n = 339) on changes in Short Physical Performance Battery (SPPB) score and its component tests, Timed Up-and-Go (TUG) test, 6-minute walk distance, and grip strength. Results: The trial enrolled 688 participants. Mean age was 77.2 years, 56.4% were male, 79.7% White, and 18.2% Black. While the PHD and control groups both lost function over time on most outcomes, the 2 groups did not show differential change overall on any outcome. Incidence of transitioning to poor functioning on gait speed, SPPB score, or TUG test did not differ by dose group. Conclusion: In older persons with low serum 25-hydroxyvitamin D level and elevated fall risk, high-dose vitamin D supplementation, ≥1 000 IU/day, did not improve measures of physical function compared to 200 IU/day.
KW - Physical functioning
KW - Randomized controlled trial
KW - Vitamin D
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U2 - 10.1093/gerona/glab379
DO - 10.1093/gerona/glab379
M3 - Article
C2 - 34928336
AN - SCOPUS:85136341861
SN - 1079-5006
VL - 77
SP - 1585
EP - 1592
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 8
ER -