Effects of ventral striatal lesions on first- and second-order appetitive conditioning

Michael A. Mcdannald, Barry Setlow, Peter C. Holland

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Rats with bilateral lesions of the ventral striatal nucleus accumbens failed to acquire Pavlovian second-order conditioning to auditory stimuli paired with visual stimuli that had previously received first-order pairings with food. This deficit in second-order conditioning was specific to learning driven by incentive properties of the first-order cues, and was observed whether the first-order training had occurred prior to or after lesion surgery. Lesions also produced deficits in the display of conditioned responses to the first-order conditioned stimulus, but only when they were made after first-order training. These results suggest a specific role for the ventral striatum in acquiring and expressing incentive properties of conditioned stimuli through second-order conditioning, as well as a more general role in expressing previously acquired Pavlovian conditioned responses.

Original languageEnglish (US)
Pages (from-to)2589-2599
Number of pages11
JournalEuropean Journal of Neuroscience
Issue number4
StatePublished - Aug 2013
Externally publishedYes


  • Conditioned reinforcement
  • Incentive learning
  • Nucleus accumbens
  • Rat

ASJC Scopus subject areas

  • General Neuroscience


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