Abstract
Vitamin A-derived retinoic acids (RAs) are known to exert a variety of biological actions, including modulatory effects on cell differentiation and apoptosis. A recent study has demonstrated that 13-cis-RA and all-trans-RA suppressed neurogenesis in the dentate gyrus of the hippocampus in adult mice. The present experiments were performed to see whether 13-cis-RA and all-trans-RA could alter the dendritic morphology of cultured hippocampal neurons via RA receptors: retinoic acid receptor (RAR) and retinoid X receptor (RXR). High doses of 13-cis-RA and all-trans-RA exerted a negative effect on the cultured hippocampal neurons, while a low dose of 13-cis-RA but not all-trans-RA caused a positive effect. The negative changes induced by 13-cis-RA and all-trans-RA were antagonized by RXR antagonists and RAR antagonists, respectively. The positive changes induced by a low dose of 13-cis-RA were blocked by both RXR antagonists and RAR antagonists. These results suggest that RAs at high concentrations cause a negative effect on the dendritic morphology of cultured hippocampal neurons through RA receptors, while RAs at low concentrations exert a positive influence on cultured hippocampal neurons.
Original language | English (US) |
---|---|
Pages (from-to) | 1104-1116 |
Number of pages | 13 |
Journal | Journal of Neurochemistry |
Volume | 106 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2008 |
Externally published | Yes |
Keywords
- Depression
- Hippocampus
- Isotretinoin
- Retinoic acid
- Retinoic acid receptor
- Retinoid X receptor
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience