Effects of renal sympathetic denervation using saline-irrigated radiofrequency ablation catheter on the activity of the renin-angiotensin system and endothelin-1

Jiayi Lu, Zhiyu Ling, Weijie Chen, Huaan Du, Yanping Xu, Jinqi Fan, Yi Long, Shaojie Chen, Peilin Xiao, Zengzhang Liu, Bernhard Zrenner, Yuehui Yin

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Excessive activation of the sympathetic nervous system (SNS) and the renin-angiotensin system (RAS) are crucial and interacted closely in the pathogenesis of chronic cardiovascular diseases. This study investigated the effects of renal denervation (RDN) on the RAS. Materials and methods: Eight Chinese Kunming dogs underwent bilateral RDN utilizing saline-irrigated radiofrequency ablation catheter. Blood pressure (BP) measurements, blood sampling assays and renal angiography were performed at baseline, 30 min, one month and three months after ablation. Results: During three months of follow-up, RDN caused a significant and uniform reduction in plasma level of renin, angiotensin II, and endothelin-1(ET-1), with the reduction of -5.7±6.8 (p=0.049), -19.4±19.3 (p=0.025), and -22.4±21 pg/ml (p=0.02) for plasma renin, -10.6±7.2 (p=0.004), -15.9±8.8 (p=0.001), and -15.2±9.6 pg/ml (p=0.003) for plasma angiotensin II, as well as -3.9±3 (p=0.007), -10.8±5 (p<0.001), and -14.6±6.1 pg/ml (p<0.001) for plasma ET-1. RDN utilizing a saline-irrigated catheter also caused a progressive and substantial BP reduction of -19±22/-8±13, -30±13/- 13±14, and -36±20/-16±14 mm Hg (p=0.045, p<0.001, and p<0.002 for systolic BP; p=0.14, p=0.036, and p=0.014 for diastolic BP) without ablation-related complications. Conclusion: RDN substantially decreased BP and also significantly decreased the plasma levels of RAS and ET-1, which might be implicated in the mechanism of BP reduction by RDN.

Original languageEnglish (US)
Pages (from-to)532-539
Number of pages8
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume15
Issue number4
DOIs
StatePublished - Dec 17 2014
Externally publishedYes

Keywords

  • endothelin-1
  • renal artery ablation
  • Renal sympathetic denervation
  • renin-angiotensin system
  • saline-irrigated radiofrequency ablation catheter

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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