Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex

Louis J. Ignarro; Arnold L. Oronsky; Robert J. Perper

doi:10.1016/0024-3205(73)90353-6

Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex

Louis J. Ignarro, Arnold L. Oronsky, Robert J. Perper

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Prostaglandin (PG) E₁, PGE₂ and PGF_2α inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF_2α accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE₁ and PGF_2α, and reduce the acceleration by PGF_2α, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE₁ and PGF_2α might be mediated by cyclic 3', 5'-adenosine monophosphate.

Original language	English (US)
Pages (from-to)	193-201
Number of pages	9
Journal	Life Sciences
Volume	12
Issue number	5 PART 1
DOIs	https://doi.org/10.1016/0024-3205(73)90353-6
State	Published - Mar 1 1973

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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title = "Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex",

abstract = "Prostaglandin (PG) E1, PGE2 and PGF2α inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF2α accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE1 and PGF2α, and reduce the acceleration by PGF2α, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE1 and PGF2α might be mediated by cyclic 3', 5'-adenosine monophosphate.",

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T1 - Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex

AU - Ignarro, Louis J.

AU - Oronsky, Arnold L.

AU - Perper, Robert J.

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Y1 - 1973/3/1

N2 - Prostaglandin (PG) E1, PGE2 and PGF2α inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF2α accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE1 and PGF2α, and reduce the acceleration by PGF2α, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE1 and PGF2α might be mediated by cyclic 3', 5'-adenosine monophosphate.

AB - Prostaglandin (PG) E1, PGE2 and PGF2α inhibit the release of enzymes from lysosomes of rat pancreas, spleen and kidney cortex in vitro. High concentrations of PGF2α accelerate the release of lysosomal enzymes. Theophylline, papaverine and adenosine 5'-tri-phosphate each potentiate the inhibition by PGE1 and PGF2α, and reduce the acceleration by PGF2α, of lysosomal enzyme release. The dibutyryl analog of cyclic 3', 5'-adenosine monophosphate inhibits, whereas cyclic 3', 5'-guanosine monophosphate accelerates lysosomal enzyme release. The data suggest that inhibition of release of lysosomal enzymes by PGE1 and PGF2α might be mediated by cyclic 3', 5'-adenosine monophosphate.

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Effects of prostaglandins on release of enzymes from lysosomes of pancreas, spleen and kidney cortex

Abstract

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