TY - JOUR
T1 - Effects of probenecid on the pharmacokinetics of allopurinol riboside
AU - Were, J. B.O.
AU - Shapiro, T. A.
PY - 1993
Y1 - 1993
N2 - Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. In this randomized, crossover evaluation in healthy volunteers, probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.
AB - Allopurinol riboside is an experimental agent for the treatment of leishmaniasis and American trypanosomiasis. Previous studies showed that after oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. In this randomized, crossover evaluation in healthy volunteers, probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027233424&partnerID=8YFLogxK
U2 - 10.1128/AAC.37.5.1193
DO - 10.1128/AAC.37.5.1193
M3 - Article
C2 - 8517715
AN - SCOPUS:0027233424
SN - 0066-4804
VL - 37
SP - 1193
EP - 1196
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 5
ER -