TY - JOUR
T1 - Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis
AU - Walsh, Thomas J.
AU - Aoki, Shizuko
AU - Mechinaud, Francoise
AU - Bacher, John
AU - Lee, James
AU - Rubin, Marc
AU - Pizzo, Philip A.
N1 - Funding Information:
From the Infectious Diseases Section, Pediatric Branch, National Cancer Institute, and the Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland
Funding Information:
Received 2 December 1988; revised 26 October 1989. Grant support: Upjohn (Kalamazoo, MI), Glaxo (Research Triangle Park, NC), and Pfizer Central Research (Groton, CT). Reprints and correspondence: Dr. Thomas J. Walsh, Infectious Diseases Section, National Cancer Institute, Bldg. 10, Rm. 13N-240, Bethesda, MD 20892.
PY - 1990/4
Y1 - 1990/4
N2 - To investigate the potential use of fluconazole for prevention and treatment of disseminated candidiasis in granulocytopenic patients, its in vivo antifungal activity was studied in three models of disseminated candidiasis in persistently granulocytopenic rabbits: acute, subacute, and chronic disseminated candidiasis. Fluconazole was compared with the combination of amphotericin B and flucytosine for preventive, early, and late treatment of disseminated candidiasis, depending on the model. Fluconazole was most effective when used for preventive or early treatment of acute and subacute disseminated candidiasis. When compared with the combination of amphotericin B plus flucytosine, fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis. When treatment was delayed 6 days after established infection, fluconazole was less active in clearing tissues in comparison with its activity in preventive and early treatment. The combination of amphotericin B plus flucytosine, however, was significantly more active than fluconazole in treatment of chronic disseminated candidiasis in all tissues. In summary, fluconazole was most effective against disseminated candidiasis in persistently granulocytopenic rabbits when used for prevention or early treatment.
AB - To investigate the potential use of fluconazole for prevention and treatment of disseminated candidiasis in granulocytopenic patients, its in vivo antifungal activity was studied in three models of disseminated candidiasis in persistently granulocytopenic rabbits: acute, subacute, and chronic disseminated candidiasis. Fluconazole was compared with the combination of amphotericin B and flucytosine for preventive, early, and late treatment of disseminated candidiasis, depending on the model. Fluconazole was most effective when used for preventive or early treatment of acute and subacute disseminated candidiasis. When compared with the combination of amphotericin B plus flucytosine, fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis. When treatment was delayed 6 days after established infection, fluconazole was less active in clearing tissues in comparison with its activity in preventive and early treatment. The combination of amphotericin B plus flucytosine, however, was significantly more active than fluconazole in treatment of chronic disseminated candidiasis in all tissues. In summary, fluconazole was most effective against disseminated candidiasis in persistently granulocytopenic rabbits when used for prevention or early treatment.
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U2 - 10.1093/infdis/161.4.755
DO - 10.1093/infdis/161.4.755
M3 - Article
C2 - 2138654
AN - SCOPUS:0025318886
SN - 0022-1899
VL - 161
SP - 755
EP - 760
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -