TY - JOUR
T1 - Effects of physical activity and sedentary time on the risk of heart failure
AU - Young, Deborah Rohm
AU - Reynolds, Kristi
AU - Sidell, Margo
AU - Brar, Somjot
AU - Ghai, Nirupa R.
AU - Sternfeld, Barbara
AU - Jacobsen, Steven J.
AU - Slezak, Jeffrey M.
AU - Caan, Bette
AU - Quinn, Virginia P.
PY - 2014/1
Y1 - 2014/1
N2 - Background.Although the benefits of physical activity for risk of coronary heart disease are well established, less is known about its effects on heart failure (HF). The risk of prolonged sedentary behavior on HF is unknown. Methods and Results.The study cohort included 82 695 men aged .45 years from the California Men-fs Health Study without prevalent HF who were followed up for 10 years. Physical activity, sedentary time, and behavioral covariates were obtained from questionnaires, and clinical covariates were determined from electronic medical records. Incident HF was identified through International Classification of Diseases, Ninth Revision codes recorded in electronic records. During a mean follow-up of 7.8 years (646 989 person-years), 3473 men were diagnosed with HF. Controlling for sedentary time, sociodemographics, hypertension, diabetes mellitus, unfavorable lipid levels, body mass index, smoking, and diet, the hazard ratio (95% confidence interval [CI]) of HF in the lowest physical activity category compared with those in the highest category was 1.52 (95% CI, 1.39.1.68). Those in the medium physical activity category were also at increased risk (hazard ratio, 1.17 [95% CI, 1.06.1.29]). Controlling for the same covariates and physical activity, the hazard ratio (95% CI) of HF in the highest sedentary category compared with the lowest was 1.34 (95% CI, 1.21.1.48). Medium sedentary time also conveyed risk (hazard ratio, 1.13 [95% CI, 1.04.1.24]). Results showed similar trends across white and Hispanic subgroups, body mass index categories, baseline hypertension status, and prevalent coronary heart disease. Conclusions.Both physical activity and sedentary time may be appropriate intervention targets for preventing HF.
AB - Background.Although the benefits of physical activity for risk of coronary heart disease are well established, less is known about its effects on heart failure (HF). The risk of prolonged sedentary behavior on HF is unknown. Methods and Results.The study cohort included 82 695 men aged .45 years from the California Men-fs Health Study without prevalent HF who were followed up for 10 years. Physical activity, sedentary time, and behavioral covariates were obtained from questionnaires, and clinical covariates were determined from electronic medical records. Incident HF was identified through International Classification of Diseases, Ninth Revision codes recorded in electronic records. During a mean follow-up of 7.8 years (646 989 person-years), 3473 men were diagnosed with HF. Controlling for sedentary time, sociodemographics, hypertension, diabetes mellitus, unfavorable lipid levels, body mass index, smoking, and diet, the hazard ratio (95% confidence interval [CI]) of HF in the lowest physical activity category compared with those in the highest category was 1.52 (95% CI, 1.39.1.68). Those in the medium physical activity category were also at increased risk (hazard ratio, 1.17 [95% CI, 1.06.1.29]). Controlling for the same covariates and physical activity, the hazard ratio (95% CI) of HF in the highest sedentary category compared with the lowest was 1.34 (95% CI, 1.21.1.48). Medium sedentary time also conveyed risk (hazard ratio, 1.13 [95% CI, 1.04.1.24]). Results showed similar trends across white and Hispanic subgroups, body mass index categories, baseline hypertension status, and prevalent coronary heart disease. Conclusions.Both physical activity and sedentary time may be appropriate intervention targets for preventing HF.
KW - Exercise
KW - Heart failure
KW - Prevention & control
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U2 - 10.1161/CIRCHEARTFAILURE.113.000529
DO - 10.1161/CIRCHEARTFAILURE.113.000529
M3 - Article
C2 - 24449810
AN - SCOPUS:84896105673
SN - 1941-3289
VL - 7
SP - 21
EP - 27
JO - Circulation: Heart Failure
JF - Circulation: Heart Failure
IS - 1
ER -