Effects of phencyclidine on the spontaneous activity of monoaminergic neurons

Srinivasa N. Raja; Patrice G. Guyenet

doi:10.1016/0014-2999(80)90452-5

Effects of phencyclidine on the spontaneous activity of monoaminergic neurons

Srinivasa N. Raja, Patrice G. Guyenet

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.

Original language	English (US)
Pages (from-to)	229-233
Number of pages	5
Journal	European Journal of Pharmacology
Volume	63
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(80)90452-5
State	Published - May 2 1980
Externally published	Yes

Keywords

Amphetamine
Monoaminergic neurons
Phencyclidine
Single unit recordings

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(80)90452-5

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title = "Effects of phencyclidine on the spontaneous activity of monoaminergic neurons",

abstract = "Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.",

keywords = "Amphetamine, Monoaminergic neurons, Phencyclidine, Single unit recordings",

author = "Raja, {Srinivasa N.} and Guyenet, {Patrice G.}",

note = "Funding Information: We wish to thank Ms. Candace Hubbard for her excellent assistance. The research was supported by NIDA Grant 1R01DA 02310-01 and the NIGMS Research Training Fellowship to S.N. Raja.",

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T1 - Effects of phencyclidine on the spontaneous activity of monoaminergic neurons

AU - Raja, Srinivasa N.

AU - Guyenet, Patrice G.

N1 - Funding Information: We wish to thank Ms. Candace Hubbard for her excellent assistance. The research was supported by NIDA Grant 1R01DA 02310-01 and the NIGMS Research Training Fellowship to S.N. Raja.

PY - 1980/5/2

Y1 - 1980/5/2

N2 - Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.

AB - Intravenous phencyclidine (PCP) increased the firing rate of a population of slow firing dopaminergic neurons recorded in the substantia nigra of chloral hydrate anesthetized rats. PCP also significantly reduced the potency of i.v. d-amphetamine to inhibit the firing of dopaminergic neurons. The drug produced little changes in the activity of serotonergic neurons of the dorsal raphe and consistently inhibited the firing of noradrenergic neurons in the locus coeruleus.

KW - Amphetamine

KW - Monoaminergic neurons

KW - Phencyclidine

KW - Single unit recordings

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Effects of phencyclidine on the spontaneous activity of monoaminergic neurons

Abstract

Keywords

ASJC Scopus subject areas

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