Effects of pH and pCO2 on performance of ischemic myocardium.

M. L. Weisfeldt, R. L. Bishop, H. L. Greene

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Contractile performance of ischemic feline myocardium was evaluated under conditions of selective changes in perfusate in pH and pCO2. A substantial increase in myocardial performance was noted when the pCO2 was lowered at constant pH, and depression of performance was noted when the pCO2 was increased at constant pH. Perfusate acidosis at constant pCO2 resulted in depression of performance and decreased performance only after 20 min of exposure. Alkalosis did not increase performance and decreased performance transiently during mild ischemia. These studies suggest that performance of myocardium during ischemia is closely related to tissue pCO2 and is minimally related to the level of extracellular pH.

Original languageEnglish (US)
Pages (from-to)355-364
Number of pages10
JournalRecent advances in studies on cardiac structure and metabolism
StatePublished - Dec 1 1975
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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