TY - JOUR
T1 - Effects of Myopia on Rates of Change in Optical Coherence Tomography Measured Retinal Layer Thicknesses in People with Multiple Sclerosis and Healthy Controls
AU - Kalaitzidis, Grigorios
AU - Pellegrini, Nicole
AU - Nagy, Natalia
AU - Vasileiou, Eleni
AU - Ehrhardt, Henrik
AU - Reppen, Abbey
AU - Murphy, Olwen C.
AU - Moussa, Hussein
AU - Filippatou, Angeliki
AU - Lambe, Jeffrey
AU - DuVal, Anna
AU - Fioravante, Nicholas
AU - Kwakyi, Ohemaa
AU - Nguyen, James
AU - Davis, Simidele
AU - Douglas, Morgan
AU - Ramirez, Alexandra
AU - Ecoff, Katie
AU - Valenzuela, Alyssandra
AU - Reyes-Mantilla, Maria
AU - Hu, Chen
AU - Fitzgerald, Kathryn C.
AU - Sotirchos, Elias S.
AU - Saidha, Shiv
AU - Calabresi, Peter A.
N1 - Funding Information:
This work was supported by the National Institute of Neurological Disorders and Stroke under the grant R01NS082347 and Fundamental Research Funds for the Central Universities, NEU.
Funding Information:
SS has received consulting fees from Medical Logix for the development of CME programs in neurology, and has served on scientific advisory boards for Biogen, Genzyme, Genentech Corporation, EMD Serono, and Celgene. He is the PI of investigator-initiated studies funded by Genentech and Biogen, was the site investigator of a trial sponsored by MedDay Pharmaceuticals and received support from the Race to Erase MS foundation. He has consulted for Carl Zeiss Meditec, and has received equity compensation for consulting from JuneBrain LLC, a retinal imaging device developer.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Purpose: To quantify the associations of myopia with longitudinal changes in retinal layer thicknesses in people with multiple sclerosis (PwMS) and healthy controls (HC). Methods: A cohort of PwMS and HC with recorded refractive error (RE) prospectively scanned on Cirrus HD-OCT at the Johns Hopkins MS Center was assessed for inclusion. Exclusion criteria included OCT follow-up < 6 months, ocular comorbidities, incidental OCT pathologies, and inadequate scan quality. Eyes were classified as having high myopia (HM) (RE≤ −6 diopters), low myopia (LM) (RE> −6 and ≤ −3 diopters), or no myopia (NM) (RE> −3 and ≤ +2.75). Linear mixed-effects regression models were used in analyses. Results: A total of 213 PwMS (eyes: 67 HM, 98 LM, 207 NM) and 80 HC (eyes: 26 HM, 37 LM, 93 NM) were included. Baseline average ganglion cell/inner plexiform (GCIPL) and peri-papillary retinal nerve fiber layer (pRNFL) thicknesses were lower in MS HM compared with MS NM (diff: −3.2 µm, 95% CI: −5.5 to −0.8, p = 0.008 and −5.3 µm, 95% CI: −9.0 to −1.7, p = 0.004, respectively), and similarly in HC HM, as compared with HC NM. Baseline superior, inferior, and nasal pRNFL thicknesses were lower in HM compared with NM, while temporal pRNFL thickness was higher, both in MS and HC (MS: 7.1 µm, 95% CI: 2.7–11.6, p = 0.002; HC: 4.7 µm, 95% CI: −0.3 to 9.7, p = 0.07). No longitudinal differences in rates of GCIPL change were noted between HM and LM vs. NM, either in MS or HC. Conclusion: Cross-sectional differences in average GCIPL and pRNFL thicknesses are commonly seen in people with HM as compared to reference normative values from people with NM and can lead to false attribution of pathology if RE is not taken into account. However, our study suggests that longitudinal changes in average GCIPL thickness in PwMS with myopia are similar in magnitude to PwMS with NM, and therefore are appropriate for monitoring disease-related pathology.
AB - Purpose: To quantify the associations of myopia with longitudinal changes in retinal layer thicknesses in people with multiple sclerosis (PwMS) and healthy controls (HC). Methods: A cohort of PwMS and HC with recorded refractive error (RE) prospectively scanned on Cirrus HD-OCT at the Johns Hopkins MS Center was assessed for inclusion. Exclusion criteria included OCT follow-up < 6 months, ocular comorbidities, incidental OCT pathologies, and inadequate scan quality. Eyes were classified as having high myopia (HM) (RE≤ −6 diopters), low myopia (LM) (RE> −6 and ≤ −3 diopters), or no myopia (NM) (RE> −3 and ≤ +2.75). Linear mixed-effects regression models were used in analyses. Results: A total of 213 PwMS (eyes: 67 HM, 98 LM, 207 NM) and 80 HC (eyes: 26 HM, 37 LM, 93 NM) were included. Baseline average ganglion cell/inner plexiform (GCIPL) and peri-papillary retinal nerve fiber layer (pRNFL) thicknesses were lower in MS HM compared with MS NM (diff: −3.2 µm, 95% CI: −5.5 to −0.8, p = 0.008 and −5.3 µm, 95% CI: −9.0 to −1.7, p = 0.004, respectively), and similarly in HC HM, as compared with HC NM. Baseline superior, inferior, and nasal pRNFL thicknesses were lower in HM compared with NM, while temporal pRNFL thickness was higher, both in MS and HC (MS: 7.1 µm, 95% CI: 2.7–11.6, p = 0.002; HC: 4.7 µm, 95% CI: −0.3 to 9.7, p = 0.07). No longitudinal differences in rates of GCIPL change were noted between HM and LM vs. NM, either in MS or HC. Conclusion: Cross-sectional differences in average GCIPL and pRNFL thicknesses are commonly seen in people with HM as compared to reference normative values from people with NM and can lead to false attribution of pathology if RE is not taken into account. However, our study suggests that longitudinal changes in average GCIPL thickness in PwMS with myopia are similar in magnitude to PwMS with NM, and therefore are appropriate for monitoring disease-related pathology.
KW - Myopia
KW - multiple sclerosis
KW - optical coherence tomography
KW - refractive error
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U2 - 10.1080/02713683.2022.2149806
DO - 10.1080/02713683.2022.2149806
M3 - Article
C2 - 36440535
AN - SCOPUS:85142874224
SN - 0271-3683
VL - 48
SP - 312
EP - 319
JO - Current Eye Research
JF - Current Eye Research
IS - 3
ER -