TY - JOUR
T1 - Effects of methotrexate on group a beta hemolytic streptococci and streptococcal infection
AU - Metcalfe, Dean
AU - Hughes, Walter T.
PY - 1972/8
Y1 - 1972/8
N2 - The incidence of Group A beta hemolytic streptococci and streptococcal infections was lower in children with leukemia than those with no malignancy. Cancer chemotherapy agents were suspected of having some effect on the microbial flora, and methotrexate was investigated. In vitro, methotrexate (MTX) was found to inhibit Group A beta hemolytic streptococci in concentrations of 7.8 μg/ml and less, whereas P. aeruginosa, E. coli, S. aureus, S. marcescens, C. albicans, and Klebsiella‐Enterobacter sp. were resistant to 250 μg/ml. In mice, early death from streptococcal infection was prevented with one injection of MTX, whereas comparable dosage in milligrams of penicillin G failed to protect the animals. These findings indicate that MTX therapy likely influences the incidence of Group A beta hemolytic streptococci and the occurrence of streptococcal infections.
AB - The incidence of Group A beta hemolytic streptococci and streptococcal infections was lower in children with leukemia than those with no malignancy. Cancer chemotherapy agents were suspected of having some effect on the microbial flora, and methotrexate was investigated. In vitro, methotrexate (MTX) was found to inhibit Group A beta hemolytic streptococci in concentrations of 7.8 μg/ml and less, whereas P. aeruginosa, E. coli, S. aureus, S. marcescens, C. albicans, and Klebsiella‐Enterobacter sp. were resistant to 250 μg/ml. In mice, early death from streptococcal infection was prevented with one injection of MTX, whereas comparable dosage in milligrams of penicillin G failed to protect the animals. These findings indicate that MTX therapy likely influences the incidence of Group A beta hemolytic streptococci and the occurrence of streptococcal infections.
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U2 - 10.1002/1097-0142(197208)30:2<588::AID-CNCR2820300240>3.0.CO;2-V
DO - 10.1002/1097-0142(197208)30:2<588::AID-CNCR2820300240>3.0.CO;2-V
M3 - Article
C2 - 5051682
AN - SCOPUS:0015381348
SN - 0008-543X
VL - 30
SP - 588
EP - 593
JO - Cancer
JF - Cancer
IS - 2
ER -