@article{ad324f62218b4489ad5d3a217b7c63fd,
title = "Effects of methamphetamine on atropine-induced conditioned gustatory avoidance",
abstract = "The repeated administration of high doses of methamphetamine (MA) has been shown to cause monoaminergic damage in rhesus monkeys and rats. In view of the purported interaction between central cholinergic and monoaminergic systems, rhesus monkeys and rats previously exposed to high doses of MA were tested in conditioned gustatory avoidance studies with atropine (a muscarinic blocker) as the unconditioned stimulus. It was observed that both rhesus monkeys and rats previously exposed to high doses of MA exhibited less of an atropine-induced avoidance than control monkeys and rats. To control for the nonspecific effects of prior exposure to stimulants, an additional group of rats previously exposed to high doses of methylphenidate ( a stimulant shown to not cause catecholaminergic damage) was tested in the same paradigm. The methylphenidate treated rats showed no change in sensitivity to atropine in the conditioned gustatory avoidance paradigm as compared to control rats which indicated that prior exposure to the nonspecific effects of a stimulant without monoaminergic alterations does not alter the sensitivity of atropine's avoidance-inducing properties. The results of these experiments imply that atropine's avoidance-inducing properties may in part be mediated through the monoaminergic system.",
keywords = "Atropine, Conditioned gustatory avoidance, Methamphetamine, Methylphenidate",
author = "Preston, {Kenzie L.} and Wagner, {George C.} and Seiden, {Lewis S.} and Schuster, {Charles R.}",
note = "Funding Information: REPEATED high dose administration of methamphetamine (MA) or amphetamine (AMPH) has been shown to cause long-lasting neuronal alterations in the dopaminergic and serotonergic nervous systems in various species. These include decreased DA and/or serotonin (5-HT) levels in various regions of the brain \[I0, 19, 23, 38, 41, 44, 47, 48, 49\], decreased tyrosine hydroxylase and tryptophan hy- droxylase activity \[1.9,45\],d ecreased DA and 5-H'I affinity uptake sites \[33, 41, 47, 48\], an increase in tr~ ter turnover \[33\], and terminal degeneration \[28,32\]. 1 ioral studies have shown that animals with MA-induc creases in DA brain levels show decreased sensitivity effects of MA and apomorphine and increased sensiti the effects of haloperidol on performance on a diffe 'Supported in part by USPHS NIDA Grants No. DA 00250.and DA 00085 (C. R. Schuster, Principal Investigator). Kenzie L. Presl supported by PHS5-T32 GM-07151 from the National Institute of General Medical Health. George C. Wagner was supported by s Fellowship. C. R. Schuster is a recipient of career scientist award DA-00024 from the National Institute on Drug Abuse and L. Seide recipient of an RSA Award MH-10562. sPresent address: Department Of Psychiatry, Johns Hopkins University, Baltimore, MD 21205. sPresent address: Department of Psychology, Rutgers University, New Brunswick, NJ 08854. 4Requests for reprints should be addressed to Charles R. Schuster. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1984",
month = apr,
doi = "10.1016/0091-3057(84)90310-1",
language = "English (US)",
volume = "20",
pages = "601--607",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",
}