Effects of leuprolide acetate on follicular fluid hormone composition at oocyte retrieval for in vitro fertilization

R. G. Brzyski; G. E. Hofmann; R. T. Scott; H. W. Jones

doi:10.1016/S0015-0282(16)53943-0

Effects of leuprolide acetate on follicular fluid hormone composition at oocyte retrieval for in vitro fertilization

R. G. Brzyski, G. E. Hofmann, R. T. Scott, H. W. Jones

Research output: Contribution to journal › Article › peer-review

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Abstract

The follicular fluid (FF) in 91 follicles from 17 women treated with leuprolide acetate (LA) before stimulation with gonadotropins for in vitro fertilization were analyzed for estradiol (E₂), progesterone (P), androstenedione, prolactin, and human chorionic gonadotropin (hCG) and compared with the concentrations in 128 follicles from 31 women treated with gonadotropins alone. The FF E₂ concentration in LA-treated patients was significantly lower than in non-LA patients for all oocyte maturational stages. Follicles containing metaphase II oocytes had significantly lower concentrations of P and hCG in LA-treated patients. These differences persisted when analysis was limited to follicles whose oocytes fertilized normally. These data indicate that in the presence of LA, normal oocyte maturation can occur despite lower intrafollicular concentrations of E₂ and P.

Original language	English (US)
Pages (from-to)	842-847
Number of pages	6
Journal	Fertility and sterility
Volume	54
Issue number	5
DOIs	https://doi.org/10.1016/S0015-0282(16)53943-0
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Effects of leuprolide acetate on follicular fluid hormone composition at oocyte retrieval for in vitro fertilization",

abstract = "The follicular fluid (FF) in 91 follicles from 17 women treated with leuprolide acetate (LA) before stimulation with gonadotropins for in vitro fertilization were analyzed for estradiol (E2), progesterone (P), androstenedione, prolactin, and human chorionic gonadotropin (hCG) and compared with the concentrations in 128 follicles from 31 women treated with gonadotropins alone. The FF E2 concentration in LA-treated patients was significantly lower than in non-LA patients for all oocyte maturational stages. Follicles containing metaphase II oocytes had significantly lower concentrations of P and hCG in LA-treated patients. These differences persisted when analysis was limited to follicles whose oocytes fertilized normally. These data indicate that in the presence of LA, normal oocyte maturation can occur despite lower intrafollicular concentrations of E2 and P.",

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T1 - Effects of leuprolide acetate on follicular fluid hormone composition at oocyte retrieval for in vitro fertilization

AU - Brzyski, R. G.

AU - Hofmann, G. E.

AU - Scott, R. T.

AU - Jones, H. W.

PY - 1990

Y1 - 1990

N2 - The follicular fluid (FF) in 91 follicles from 17 women treated with leuprolide acetate (LA) before stimulation with gonadotropins for in vitro fertilization were analyzed for estradiol (E2), progesterone (P), androstenedione, prolactin, and human chorionic gonadotropin (hCG) and compared with the concentrations in 128 follicles from 31 women treated with gonadotropins alone. The FF E2 concentration in LA-treated patients was significantly lower than in non-LA patients for all oocyte maturational stages. Follicles containing metaphase II oocytes had significantly lower concentrations of P and hCG in LA-treated patients. These differences persisted when analysis was limited to follicles whose oocytes fertilized normally. These data indicate that in the presence of LA, normal oocyte maturation can occur despite lower intrafollicular concentrations of E2 and P.

AB - The follicular fluid (FF) in 91 follicles from 17 women treated with leuprolide acetate (LA) before stimulation with gonadotropins for in vitro fertilization were analyzed for estradiol (E2), progesterone (P), androstenedione, prolactin, and human chorionic gonadotropin (hCG) and compared with the concentrations in 128 follicles from 31 women treated with gonadotropins alone. The FF E2 concentration in LA-treated patients was significantly lower than in non-LA patients for all oocyte maturational stages. Follicles containing metaphase II oocytes had significantly lower concentrations of P and hCG in LA-treated patients. These differences persisted when analysis was limited to follicles whose oocytes fertilized normally. These data indicate that in the presence of LA, normal oocyte maturation can occur despite lower intrafollicular concentrations of E2 and P.

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Effects of leuprolide acetate on follicular fluid hormone composition at oocyte retrieval for in vitro fertilization

Abstract

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