Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells

Aspasia Katragkou; Maria Simitsopoulou; Athanasios Chatzimoschou; Elpiniki Georgiadou; Thomas J. Walsh; Emmanuel Roilides

doi:10.1016/j.cyto.2011.05.007

Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells

Aspasia Katragkou, Maria Simitsopoulou, Athanasios Chatzimoschou, Elpiniki Georgiadou, Thomas J. Walsh, Emmanuel Roilides

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Candida albicans is a leading cause of biofilm-related infections. As Candida biofilms are recalcitrant to host defenses, we sought to determine the effects of interferon-γ and granulocyte colony-stimulating factor, two pro-inflammatory cytokines, on the antifungal activities of human polymorphonuclear neutrophils (PMNs) against C. albicans biofilms, using an in vitro biofilm model. Priming of PMNs by these cytokines augmented fungal damage of planktonic cells; however, priming of PMNs did not have the same effect against Candida biofilms. Biofilm phenotype appears to play an important role in protecting C. albicans from the innate immune system.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Cytokine
Volume	55
Issue number	3
DOIs	https://doi.org/10.1016/j.cyto.2011.05.007
State	Published - Sep 2011
Externally published	Yes

Keywords

Biofilm
Candida albicans
G-CSF
IFN-γ
Neutrophils

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Hematology
Molecular Biology

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10.1016/j.cyto.2011.05.007

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Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells. / Katragkou, Aspasia; Simitsopoulou, Maria; Chatzimoschou, Athanasios et al.
In: Cytokine, Vol. 55, No. 3, 09.2011, p. 330-334.

Research output: Contribution to journal › Article › peer-review

Katragkou, A, Simitsopoulou, M, Chatzimoschou, A, Georgiadou, E, Walsh, TJ & Roilides, E 2011, 'Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells', Cytokine, vol. 55, no. 3, pp. 330-334. https://doi.org/10.1016/j.cyto.2011.05.007

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abstract = "Candida albicans is a leading cause of biofilm-related infections. As Candida biofilms are recalcitrant to host defenses, we sought to determine the effects of interferon-γ and granulocyte colony-stimulating factor, two pro-inflammatory cytokines, on the antifungal activities of human polymorphonuclear neutrophils (PMNs) against C. albicans biofilms, using an in vitro biofilm model. Priming of PMNs by these cytokines augmented fungal damage of planktonic cells; however, priming of PMNs did not have the same effect against Candida biofilms. Biofilm phenotype appears to play an important role in protecting C. albicans from the innate immune system.",

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author = "Aspasia Katragkou and Maria Simitsopoulou and Athanasios Chatzimoschou and Elpiniki Georgiadou and Walsh, {Thomas J.} and Emmanuel Roilides",

note = "Funding Information: This study was partially supported by the Aristotle University, Thessaloniki, Greece, by a grant from the European Society of Pediatric Infectious Diseases (2006–2007 Small Grant Awards) and by a grant from Pfizer (GA900095). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

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AU - Georgiadou, Elpiniki

AU - Walsh, Thomas J.

AU - Roilides, Emmanuel

N1 - Funding Information: This study was partially supported by the Aristotle University, Thessaloniki, Greece, by a grant from the European Society of Pediatric Infectious Diseases (2006–2007 Small Grant Awards) and by a grant from Pfizer (GA900095). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

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Effects of interferon-γ and granulocyte colony-stimulating factor on antifungal activity of human polymorphonuclear neutrophils against Candida albicans grown as biofilms or planktonic cells

Abstract

Keywords

ASJC Scopus subject areas

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