Effects of indomethacin on renal inner medullary plasma flow

Kim Solez; Jennifer A. Fox; Marilyn Miller; Robert H. Heptinstall

doi:10.1016/0090-6980(74)90126-9

Effects of indomethacin on renal inner medullary plasma flow

Kim Solez, Jennifer A. Fox, Marilyn Miller, Robert H. Heptinstall

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.

Original language	English (US)
Pages (from-to)	91-98
Number of pages	8
Journal	Prostaglandins
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0090-6980(74)90126-9
State	Published - Jul 25 1974
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Endocrinology

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10.1016/0090-6980(74)90126-9

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title = "Effects of indomethacin on renal inner medullary plasma flow",

abstract = "The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.",

author = "Kim Solez and Fox, {Jennifer A.} and Marilyn Miller and Heptinstall, {Robert H.}",

note = "Funding Information: We wish to express our appreciation to Patricia Bulluck for typing the manuscript. This study was supported in part by United States Public Health Service Grants HL-07835 and GM-00415.",

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T1 - Effects of indomethacin on renal inner medullary plasma flow

AU - Solez, Kim

AU - Fox, Jennifer A.

AU - Miller, Marilyn

AU - Heptinstall, Robert H.

N1 - Funding Information: We wish to express our appreciation to Patricia Bulluck for typing the manuscript. This study was supported in part by United States Public Health Service Grants HL-07835 and GM-00415.

PY - 1974/7/25

Y1 - 1974/7/25

N2 - The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.

AB - The effects of the prostaglandin system on renal hemodynamics were studied by treating rats with a single intraperitoneal dose of indomethacin, an inhibitor of prostaglandin synthesis. Medullary plasma flow was significantly reduced 30-45 minutes after indomethacin, but was elevated 3-6 hours after indomethacin. These changes in medullary plasma flow correlated well with circulating levels of prostaglandins A and E. Total renal blood flow decreased following indomethacin treatment, but returned to normal levels within an hour. These results indicate that the inhibition of prostaglandin synthesis following a single intraperitoneal dose of indomethacin is short-lived and is followed by a significant elevation in prostaglandin synthesis. It is likely that prostaglandin levels play an important role in the control of renal medullary plasma flow.

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Effects of indomethacin on renal inner medullary plasma flow

Abstract

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