Effects of hepatitis c and hiv on cognition in women: Data from the women's interagency HIV study

Howard Crystal, Inna Kleyman, Kathryn Anastos, Jason Lazar, Mardge Cohen, Chenglong Liu, Leigh Pearce, Elizabeth Golub, Victor Valcour, Ann Ho, Howard Strickler, Marion Peters, Andrea Kovacs, Susan Holman, Mary Jeanne Kreek, Jennifer Manly

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective: To compare neuropsychological scores in women infected with HIV, women infected with both HIV and hepatitis C, and uninfected subjects. Background: Some, but not all, studies have demonstrated that dual infection with Hepatitis C virus (HCV) and HIV has worse effects on cognition than infection with HIV alone. Design/Methods: The Women's Interagency HIV Study is an ongoing prospective study of the natural history of HIV in women where participants are reevaluated every 6 months. In a crosssectional analysis, we evaluated the effects of active HIV and HCV infections on scores on symbol-digit modalities test, the Stroop interference test, and trails A and B after controlling for age, ethnicity, education, depression, liver disease, and current or past substance abuse. Results: Data were available for 1338 women-17.8 % had detectable hepatitis C virus and 67% were HIV seropositive. In fully adjusted general linear models, HCV viremia was not associated with scores on any of the cognitive tests. Conclusions: In this large sample of women, active HCV infection was not associated with scores on a small battery of neuropsychological tests.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Issue number2
StatePublished - Feb 1 2012


  • HIV
  • Hepatitis C
  • Neurocognition
  • Women

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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