@article{1814903392874addb5f99591253ae262,
title = "Effects of gestational exposure to perfluorooctane sulfonate on the lung development of offspring rats",
abstract = "Summary of the main finding: Gestational exposure to perfluorooctane sulfonate inhibited lung development of F1 offspring by down-regulation of HIF-1α/VEGFA and up-regulation of inflammasome functions.",
keywords = "Lung development, NLRP3 inflammasome, Perfluorooctane sulfonate, Pyroptosis, VEGFA",
author = "Huishan Zhang and Hemin Lu and Lin Yu and Jiexin Yuan and Shan Qin and Cong Li and Ge, {Ren Shan} and Haolin Chen and Leping Ye",
note = "Funding Information: The up-regulation of inflammatory responses by PFOS exposure was also supported by the immunohistochemical data. The staining of the key inflammasome protein NLRP3 in lung tissue suggests that inflammation not only happened in inflammatory cells, such as macrophages, neutrophils and monocytes, but also in bronchial epithelial cells. PFOS exposure resulted in a dose-dependent increase in its protein levels. Increased IL-18 and IL-1β levels also support the effects of PFOS on inflammatory responses in lung tissue. Since one of the major functions of the inflammasome is to promote proteolytic cleavage, maturation and secretion of pro-inflammatory cytokines IL-18 and IL-1β, increases in their concentrations in lung tissue are reliable markers for inflammasome activation. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2021",
month = mar,
day = "1",
doi = "10.1016/j.envpol.2020.115535",
language = "English (US)",
volume = "272",
journal = "Environmental Pollution",
issn = "0269-7491",
publisher = "Elsevier Limited",
}