Effects of fortified milk on morbidity in young children in north India: Community based, randomised, double masked placebo controlled trial

Sunil Sazawal, Usha Dhingra, Girish Hiremath, Jitendra Kumar, Pratibha Dhingra, Archana Sarkar, Venugopal P. Menon, Robert E. Black

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Objective: To evaluate the efficacy of milk fortified with specific multiple micronutrients on morbidity in children compared with the same milk without fortification. Design: Community based, double masked, individually randomised trial. Setting: Peri-urban settlement in north India. Participants: Children (n=633) aged 1-3 randomly allocated to receive fortified milk (n=316) or control milk (n=317). Intervention: One year of fortified milk providing additional 7.8 mg zinc, 9.6 mg iron, 4.2 μg selenium, 0.27 mg copper, 156 μg vitamin A, 40.2 mg vitamin C, 7.5 mg vitamin E per day (three feeds). Main outcome measures: Days with severe illnesses, incidence and prevalence of diarrhoea, and acute lower respiratory illness. Results: Study groups were comparable at baseline; compliance in the groups was similar. Mean number of episodes of diarrhoea per child was 4.46 (SD 3.8) in the intervention (fortified milk) group and 5.36 (SD 4.1) in the control group. Mean number of episodes of acute lower respiratory illness was 0.62 (SD 1.1) and 0.83 (SD 1.4), respectively. The fortified milk reduced the odds for days with severe illnesses by 15% (95% confidence interval 5% to 24%), the incidence of diarrhoea by 18% (7% to 27%), and the incidence of acute lower respiratory illness by 26% (3% to 43%). Consistently greater beneficial effects were observed in children aged <24 months than in older children. Conclusion: Milk is well accepted as a means of delivery of micronutrients. Consumption of milk fortified with specific micronutrients can significantly reduce the burden of common morbidities among preschool children, especially in the first two years of life.

Original languageEnglish (US)
Pages (from-to)140-142
Number of pages3
JournalBritish medical journal
Volume334
Issue number7585
DOIs
StatePublished - Jan 20 2007

ASJC Scopus subject areas

  • General Medicine

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