Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients

Rudolf Hoehn-Saric; Godfrey D. Pearlson; Gordon J. Harris; Steven R. Machlin; Edwaldo E. Camargo

doi:10.1176/ajp.148.9.1243

Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients

Rudolf Hoehn-Saric, Godfrey D. Pearlson, Gordon J. Harris, Steven R. Machlin, Edwaldo E. Camargo

School of Medicine

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.

Original language	English (US)
Pages (from-to)	1243-1245
Number of pages	3
Journal	American Journal of Psychiatry
Volume	148
Issue number	9
DOIs	https://doi.org/10.1176/ajp.148.9.1243
State	Published - 1991

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.148.9.1243

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Effects of fluoxetine on regional cerebral blood flow in obsessive-compulsive patients

Abstract

ASJC Scopus subject areas

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