Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract

Markad V. Kamath, Andrew May, Stephan Hollerbach, Debbie Fitzpatrick, Robert Bulat, Absar Bajwa, Gervais Tougas, Ernest L. Fallen, Glen Shine, Adrian R. Upton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 1 μV in controls, p < 0.04), while peak latencies were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalCritical reviews in biomedical engineering
Issue number1-2
StatePublished - 2000
Externally publishedYes


  • Autonomic nervous system
  • Diabetes
  • Evoked potentials
  • Heart rate variability
  • Non-cardiac chest pain

ASJC Scopus subject areas

  • Biomedical Engineering


Dive into the research topics of 'Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract'. Together they form a unique fingerprint.

Cite this