Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract

Markad V. Kamath; Andrew May; Stephan Hollerbach; Debbie Fitzpatrick; Robert Bulat; Absar Bajwa; Gervais Tougas; Ernest L. Fallen; Glen Shine; Adrian R. Upton

doi:10.1615/critrevbiomedeng.v28.i12.150

Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract

Markad V. Kamath, Andrew May, Stephan Hollerbach, Debbie Fitzpatrick, Robert Bulat, Absar Bajwa, Gervais Tougas, Ernest L. Fallen, Glen Shine, Adrian R. Upton

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 1 μV in controls, p < 0.04), while peak latencies were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

Original language	English (US)
Pages (from-to)	87-93
Number of pages	7
Journal	Critical reviews in biomedical engineering
Volume	28
Issue number	1-2
DOIs	https://doi.org/10.1615/critrevbiomedeng.v28.i12.150
State	Published - 2000
Externally published	Yes

Keywords

Autonomic nervous system
Diabetes
Evoked potentials
Heart rate variability
Non-cardiac chest pain

ASJC Scopus subject areas

Biomedical Engineering

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10.1615/critrevbiomedeng.v28.i12.150

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abstract = "We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 1 μV in controls, p < 0.04), while peak latencies were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.",

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AU - Kamath, Markad V.

AU - May, Andrew

AU - Hollerbach, Stephan

AU - Fitzpatrick, Debbie

AU - Bulat, Robert

AU - Bajwa, Absar

AU - Tougas, Gervais

AU - Fallen, Ernest L.

AU - Shine, Glen

AU - Upton, Adrian R.

PY - 2000

Y1 - 2000

N2 - We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 1 μV in controls, p < 0.04), while peak latencies were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

AB - We studied the effects of esophageal electrical stimulation on cortical-evoked potentials (EPs) and power spectrum of heart rate variability (PS/HRV) in patients with diabetes and non-cardiac chest pain (NCCP). We also recorded cognitive-evoked potentials (P300 EPs) in response to an odd-ball stimulation in patients with NCCP. Diabetic patients did not yield reproducible cortical EPs. Their power spectra of heart rate variability (PS/HRV) showed an increased vagal modulation during stimulation. In patients with NCCP the P300 EPs were of greater amplitude (17 ± 3 μV vs. 12 ± 1 μV in controls, p < 0.04), while peak latencies were slightly elongated in patients (382 ± 22 ms vs. 354 ± 12 ms in controls). The PS/HRV in these patients also showed an increased vagal modulation of the sinus node activity. Our results suggest the following: (1) in patients with diabetes, afferent pathways and processing of sensory signals are likely to be impaired; (2) an increased perception of esophageal stimulation reflects an exaggerated brainstem response and altered cortical processing of visceral sensation in patients with NCCP.

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Effects of esophageal stimulation in patients with functional disorders of the gastrointestinal tract

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Keywords

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