Abstract
Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.
Original language | English (US) |
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Pages (from-to) | 769-775 |
Number of pages | 7 |
Journal | Life Sciences |
Volume | 3 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1964 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)