Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites

Jose Musacchio; Irwin J. Kopin; Solomon Snyder

doi:10.1016/0024-3205(64)90032-3

Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites

Jose Musacchio, Irwin J. Kopin, Solomon Snyder

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65 Scopus citations

Abstract

Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.

Original language	English (US)
Pages (from-to)	769-775
Number of pages	7
Journal	Life Sciences
Volume	3
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(64)90032-3
State	Published - Jul 1964
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(64)90032-3

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title = "Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites",

abstract = "Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.",

author = "Jose Musacchio and Kopin, {Irwin J.} and Solomon Snyder",

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AU - Musacchio, Jose

AU - Kopin, Irwin J.

AU - Snyder, Solomon

PY - 1964/7

Y1 - 1964/7

N2 - Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.

AB - Disulfiram has been shown to markedly inhibit dopamine-β-hydroxylase in vivo and to result in a decrease in norepinephrine content of tissues, presumably by making β-hydroxylation rate limiting. Disulfiram also inhibits the β-hydroxylation of tyramine to octopamine. While β-hydroxylation of tyramine appears to be necessary for retention by sympathetic vesicles, dopamine can be retained by the vesicles when β-hydroxylation is inhibited.

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ER -

Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their β-hydroxylated metabolites

Abstract

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