Effects of cocaine on sensory motor function in baboons

Robert D. Hienz; Debra J. Spear; Joseph V. Brady; Danielle A. Bowers

doi:10.1016/0091-3057(93)90257-T

Effects of cocaine on sensory motor function in baboons

Robert D. Hienz, Debra J. Spear, Joseph V. Brady, Danielle A. Bowers

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.

Original language	English (US)
Pages (from-to)	399-408
Number of pages	10
Journal	Pharmacology, Biochemistry and Behavior
Volume	45
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(93)90257-T
State	Published - Jun 1993

Keywords

Baboon
Cocaine
Lever press
Psychophysical procedure
Reaction time
Threshold

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

Access to Document

10.1016/0091-3057(93)90257-T

Cite this

@article{640ad5f167a64a4eb1b8ab542b3a00de,

title = "Effects of cocaine on sensory motor function in baboons",

abstract = "The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.",

keywords = "Baboon, Cocaine, Lever press, Psychophysical procedure, Reaction time, Threshold",

author = "Hienz, {Robert D.} and Spear, {Debra J.} and Brady, {Joseph V.} and Bowers, {Danielle A.}",

year = "1993",

month = jun,

doi = "10.1016/0091-3057(93)90257-T",

language = "English (US)",

volume = "45",

pages = "399--408",

journal = "Pharmacology, Biochemistry and Behavior",

issn = "0091-3057",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Effects of cocaine on sensory motor function in baboons

AU - Hienz, Robert D.

AU - Spear, Debra J.

AU - Brady, Joseph V.

AU - Bowers, Danielle A.

PY - 1993/6

Y1 - 1993/6

N2 - The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.

AB - The effects of cocaine on auditory and visual threshold functions and reaction times were studied in baboons. Single IM injections of cocaine HCl (0.001-1.0 mg/kg) were administered once or twice weekly and were followed immediately by psychophysical tests designed to assess cocaine's effects on sensory thresholds and reaction times. Consistent reductions in reaction times were observed in the cocaine dose range of 0.032-0.32 mg/kg. Reaction times were decreased by 5-8% at the more effective cocaine doses. Concurrently measured auditory and visual threshold sensitivities showed no systematic changes at any of the cocaine doses studied.

KW - Baboon

KW - Cocaine

KW - Lever press

KW - Psychophysical procedure

KW - Reaction time

KW - Threshold

UR - http://www.scopus.com/inward/record.url?scp=0027230347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027230347&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(93)90257-T

DO - 10.1016/0091-3057(93)90257-T

M3 - Article

C2 - 8327546

AN - SCOPUS:0027230347

SN - 0091-3057

VL - 45

SP - 399

EP - 408

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 2

ER -

Effects of cocaine on sensory motor function in baboons

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this