TY - JOUR
T1 - Effects of carbon dioxide therapy on the healing of acute skin wounds induced on the back of rats
AU - Penhavel, Maria Vitória Carmo
AU - Nascimento, Victor Henrique Tavares
AU - Durães, Eliana Ferreira Ribeiro
AU - Carneiro, Fabiana Pirani
AU - de Sousa, João Batista
PY - 2013/5
Y1 - 2013/5
N2 - PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
AB - PURPOSE: To evaluate the healing effect of carbon dioxide therapy on skin wounds induced on the back of rats. METHODS: Sixteen rats underwent excision of a round dermal-epidermal dorsal skin flap of 2.5 cm in diameter. The animals were divided into two groups, as follows: carbon dioxide group - subcutaneous injections of carbon dioxide on the day of operation and at three, six and nine days postoperatively; control group - no postoperative wound treatment. Wounds were photographed on the day of operation and at six and 14 days postoperatively for analysis of wound area and major diameter. All animals were euthanized on day 14 after surgery. The dorsal skin and the underlying muscle layer containing the wound were resected for histopathological analysis. RESULTS: There was no statistically significant difference between groups in the percentage of wound closure, in histopathological findings, or in the reduction of wound area and major diameter at 14 days postoperatively. CONCLUSION: Under the experimental conditions in which this study was conducted, carbon dioxide therapy had no effects on the healing of acute skin wounds in rats.
KW - Carbon dioxide
KW - Rats
KW - Skin
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84878324522&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878324522&partnerID=8YFLogxK
U2 - 10.1590/S0102-86502013000500003
DO - 10.1590/S0102-86502013000500003
M3 - Article
C2 - 23702934
AN - SCOPUS:84878324522
SN - 0102-8650
VL - 28
SP - 334
EP - 339
JO - Acta cirurgica brasileira
JF - Acta cirurgica brasileira
IS - 5
ER -